ArticleTranslational research : the journal of laboratory and clinical medicine2021
Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota.
Article in Translational research : the journal of laboratory and clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Circadian rhythms regulate osteoclast recycling through gut microbiota-dependent Th17 cell expansion.Current research in microbial sciences · 2026Article
- Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Health.Gastroenterology · 2025Review
- The circadian rhythm as therapeutic target in inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025Article
- Leaky Gut Syndrome: An Interplay Between Nutrients and Dysbiosis.Current nutrition reports · 2025Review
- Gut jet lag: how circadian rhythm disruption undermines the Chrono-Microbiota-Motility axis and induces functional constipation.Frontiers in nutrition · 2025Review
- Sleep deprivation-induced anxiety-like behaviors are associated with alterations in the gut microbiota and metabolites.Microbiology spectrum · 2024Article
- Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging.Microbiome · 2024Article
- Gut microbiota: a potential influencer of insomnia occurring after COVID-19 infection.Frontiers in psychiatry · 2024Review
- Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets.Cancer metastasis reviews · 2023Review
- Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy.Frontiers in nutrition · 2023Review
- Could "Eating Behavior" be a novel lifestyle factor that modulates risk of gastrointestinal cancers?Hepatobiliary surgery and nutrition · 2022Article
- Behavioral circadian phenotypes are associated with the risk of elevated body mass index.Eating and weight disorders : EWD · 2022Article
- Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Inconsistent eating time is associated with obesity: A prospective study.EXCLI journal · 2022Article
- Feeding Frequency Modulates the Intestinal Transcriptome Without Affecting the Gut Microbiota in Pigs With the Same Daily Feed Intake.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Obesity has become a common rising health care problem, especially in "modern" societies. Obesity is considered a low-grade systemic inflammation, partly linked to leaky gut. Circadian rhythm disruption, a common habit in modern life, has been reported to cause gut barrier impairment. Abnormal time of eating, defined by eating close to or during rest time, is shown to cause circadian rhythm disruption. Here, using a non-obesogenic diet, we found that abnormal feeding time facilitated weight gain and induced metabolic dysregulation in mice. The effect of abnormal time of eating was associated with increased gut permeability, estimated by sucralose and/or lactulose ratio and disrupted intestinal barrier marker. Analysis of gut microbiota and their metabolites, as important regulators of barrier homeostasis, revealed that abnormal food timing reduced relative abundance of butyrate-producing bacteria, and the colonic butyrate level. Overall, our data supported that dysbiosis was characterized by increased intestinal permeability and decreased beneficial barrier butyrate-producing bacteria and/or metabolite to mechanistically link the time of eating to obesity. This data provides basis for noninvasive microbial-targeted interventions to improve intestinal barrier function as new opportunities for combating circadian rhythm disruption induced metabolic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.