Evidence map›Paper›PMID 33221457›Full record

ArticlePhytomedicine : international journal of phytotherapy and phytopharmacology2021

Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.

David Y W Lee, Qing Y Li, Jing Liu, Thomas Efferth

Open access · greenAbstract read
In one paragraph

Article in Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
27.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.

  1. Pooled it
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  10. [Role of Traditional Chinese Medicine in Pathogen-Induced Metabolic Reprogramming and Immune Suppression].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
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  19. Discovery of Anti-Coronavirus Cinnamoyl Triterpenoids Isolated fromInternational journal of molecular sciences · 2023
    Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

David Y W LeeBio-Organic and Natural Products Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478. Electronic address: dle@mclean.harvard.edu.
Qing Y LiBio-Organic and Natural Products Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478; Henan University of Chinese Medicine, Zhengzhou, China 450046.
Jing LiuBio-Organic and Natural Products Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478.
Thomas EfferthDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany 55128. Electronic address: efferth@uni-mainz.de.
Harvard University · USJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThroughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics' infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. APPROACH: We conducted conduct a systematic survey of various TCM herbal preparations used in Wuhan and to review their efficacy, according to the published clinical data; and, secondly, to find the most popular herbs used in these preparations and look into the opportunity of future research in the isolation and identification of bioactive natural products for fighting COVID-19.

resultsAlthough bioactive natural products in these herbal preparations may have direct antiviral activities, TCM employed for fighting epidemic infections was primarily based on the TCM theory of restoring the balance of the human immune system, thereby defeating the viral infection indirectly. In addition, certain TCM teachings relevant to the meridian system deserve better attention. For instance, many TCM herbal preparations target the lung meridian, which connects the lung and large intestine. This interconnection between the lung, including the upper respiratory system, and the intestine, may explain why certain TCM formulae showed excellent relief of lung congestion and diarrhea, two characteristics of COVID-19 infection.

conclusionThere is good reason for us to learn from ancient wisdom and accumulated clinical experience, in combination with cutting edge science and technologies, to fight with the devastating COVID-19 pandemic now and emerging new coronaviruses in the future.

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsChinaClinical Trials as TopicCOVID-19Drugs, Chinese HerbalHumansMedicine, Chinese TraditionalPlants, MedicinalSARS-CoV-2Antiviral AgentsDrugs, Chinese HerbalMedicinal herbPhytotherapySARS-CoV-2Viral infection

Identifiers

PMID33221457
PMCPMC7521884
OpenAlexW3088639750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.