ArticleGynecologic oncology2021
Factors associated with endometrial cancer and hyperplasia among middle-aged and older Hispanics.
Article in Gynecologic oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association of endometrial cancer risk with hypertension- an updated meta-analysis of observational studies.Scientific reports · 2024Pooled it
- Development of a clinical prediction model for pathological upgrade from endometrial atypical hyperplasia to endometrial cancer: a retrospective Eastern Chinese cohort study.AJOG global reports · 2026Article
- Diabetes mellitus and risk of endometrial cancer: an updated systematic review and meta-analysis.Acta diabetologica · 2026Review
- Comparison of Surgical Outcomes Among Open, Laparoscopic, and Robotic Surgeries in Women with Obesity Diagnosed with Endometrial Cancer: Results from a Quaternary Hospital in Thailand.International journal of women's health · 2026Article
- Medical and Social Characteristics of Patients with Endometrial Hyperplasia in a Large City in Kazakhstan: A Retrospective Comparative Study.Healthcare (Basel, Switzerland) · 2025Article
- Trends in endometrial cancer incidence in the United States by race/ethnicity and age of onset from 2000 to 2019.American journal of epidemiology · 2025Article
- Evaluation of the impact of diabetes mellitus on endometrial cancer risk: an updated meta-analysis of case-control studies.Archives of medical science : AMS · 2024Article
- Risk-stratification machine learning model using demographic factors, gynaecological symptoms and β-catenin for endometrial hyperplasia and carcinoma: a cross-sectional study.BMC women's health · 2023Article
- An Immune-Related Long Noncoding RNA Signature as a Prognostic Biomarker for Human Endometrial Cancer.Journal of oncology · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWhile disparities in endometrial hyperplasia and endometrial cancer are well documented in Blacks and Whites, limited information exists for Hispanics. The objective is to describe the patient characteristics associated with endometrial hyperplasia symptoms, endometrial hyperplasia with atypia and endometrial cancer, and assess factors contributing to racial/ethnic differences in disease outcomes.
methodsThis single-center, retrospective study included women aged ≥50 years with ≥ two encounters for endometrial hyperplasia symptoms, endometrial hyperplasia with atypia and endometrial cancer between 2012 and 2016. Multivariate logistic regression models evaluated the predictors of endometrial cancer and hyperplasia.
resultsWe included 19,865 women (4749 endometrial hyperplasia symptoms, 71 endometrial hyperplasias with atypia, 201 endometrial cancers) with mean age of 60.45 years (SD 9.94). The odds of endometrial hyperplasia symptoms were higher in non-Hispanic Blacks (Odds Ratio [OR] 1.56, 95% Confidence Interval [CI] 1.20-1.72), Hispanics (OR 1.35, 95% CI 1.22-1.49), family history of female cancer (OR 1.25, 95% CI 1.12-1.39), hypertension (OR 1.24, 95% CI 1.14-1.35), and birth control use (OR 1.29, 95% CI 1.15-1.43). Odds of endometrial cancer and atypical hyperplasia increased for ages 60-64 (OR 7.95, 95% CI 3.26-19.37; OR 3.66, 95% 1.01-13.22) and being obese (OR 1.61, 95% CI 1.08-2.41; OR: 6.60, 95% CI 2.32-18.83). Odds of endometrial cancer increased with diabetes (OR 1.68, 95% CI 1.22-2.32). CONCLUSION(S): Patients with obesity and diabetes had increased odds of endometrial cancer and hyperplasia with atypia. Further study is needed to understand the exogenous estrogen effect contributing to the increased incidence among Hispanics.
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