ArticleAlzheimer's research & therapy2020
Smaller pineal gland is associated with rapid eye movement sleep behavior disorder in Alzheimer's disease.
Article in Alzheimer's research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Prevalence and clinical implications of Rapid eye movement sleep behavior disorder in Alzheimer's disease and Lewy body dementia.GeroScience · 2026Observational
- Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions.Journal of advanced research · 2026Review
- Health-related factors and their impact on blood-based biomarkers of Alzheimer's disease.Aging brain · 2026Article
- Psychotic major depressive disorder and rapid eye movement sleep behavior disorder cooccurring with a pineal cyst: a case report with neuroimaging insights in a 15-year-old female.BMC psychiatry · 2025Article
- Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Demonstrates That Sleep Disorders Exacerbate Glymphatic Circulatory Impairment and Cognitive Impairment in Patients with Alzheimer's Disease.Nature and science of sleep · 2024Article
- Predictive Modeling Using a Composite Index of Sleep and Cognition in the Alzheimer's Continuum: A Decade-Long Historical Cohort Study.Journal of Alzheimer's disease reports · 2024Article
- Role of Nutritional Support under Clinical Nursing Path on the Efficacy, Quality of Life, and Nutritional Status of Elderly Patients with Alzheimer's Disease.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Smaller pineal volume in Alzheimer's disease than in dementia with Lewy bodies.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the association between pineal gland volume and symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) in Alzheimer's disease (AD) patients without any feature of dementia with Lewy bodies.
methodsWe enrolled 296 community-dwelling probable AD patients who did not meet the diagnostic criteria for possible or probable dementia with Lewy bodies. Among them, 93 were amyloid beta (Aβ) positive on
resultsThe participants with pRBD had smaller pineal parenchyma volume (VPP) than those without pRBD (p < 0.001). The smaller the VPP, the more severe the RBD symptoms (p < 0.001). VPP was inversely associated with risk of prevalent pRBD (odds ratio = 0.909, 95% confidence interval [CI] = 0.878-0.942, p < 0.001). Area under the receiver operator characteristic curve for pRBD of VPP was 0.80 (95% CI = 0.750-0.844, p < 0.0001). These results were not changed when we analyzed the 93 participants with Aβ-positive AD separately.
conclusionsIn AD patients, reduced pineal gland volume may be associated with RBD.
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