ArticleThe American journal of pathology1987
Utilization of monoclonal antibody L26 in the identification and confirmation of B-cell lymphomas. A sensitive and specific marker applicable to formalin-and B5-fixed, paraffin-embedded tissues.
Article in The American journal of pathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 139 citations in OpenAlex.
- Primary breast lymphoma initially diagnosed as invasive ductal carcinoma: A case report.Clinical case reports · 2021Article
- Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework.The American journal of pathology · 2003Article
- CD markers in pituitary adenomas.Endocrine pathology · 2001Article
- Immunophenotyping of acute lymphoblastic leukaemia in routinely processed bone marrow biopsy specimens.Journal of clinical pathology · 1999Article
- Antibody panel in diagnosis of lymphoid neoplasms.Journal of clinical pathology · 1998Article
- Sinus-lining cells of the lymph nodes recognized as a dendritic cell type by the new monoclonal antibody Ki-M9.The American journal of pathology · 1997Article
- Primary non-Hodgkin's lymphoma of the vagina. Case report and review of the literature.Annals of hematology · 1995Review
- White pulp reconstitution after human bone marrow transplantation.The American journal of pathology · 1993Article
- The bcl-2 gene translocation is undetectable in Hodgkin's disease by Southern blot hybridization and polymerase chain reaction.The American journal of pathology · 1992Article
- Phenotypic and genotypic lineage switch of a lymphoma with shared chromosome translocation and T-cell receptor gamma gene rearrangement.Japanese journal of cancer research : Gann · 1992Article
- Diffuse lymphocyte-predominant Hodgkin's disease (diffuse paragranuloma). A variant of the B-cell-derived nodular type.The American journal of pathology · 1991Article
- Primary orbital malignant lymphoma: a clinicopathology study of 17 cases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1991Article
- Sinonasal non-Hodgkin's lymphomas and Wegener's granulomatosis: a clinicopathological study.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
- Double and triple immunocytochemical labelling at the light microscope level in histopathology.The Histochemical journal · 1990Article
- Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.The American journal of pathology · 1990Article
- Monoclonal antibody HML-1, a marker for intraepithelial T cells and lymphomas derived thereof, also recognizes hairy cell leukemia and some B-cell lymphomas.The American journal of pathology · 1990Article
- Diagnosis of primary cerebral lymphoma with particular reference to CT-guided stereotactic biopsy.Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
- Glucocorticoid therapy obscures the diagnosis of cerebral lymphoma.Acta neuropathologica · 1990Article
- Monomorphic lymphomas arising in patients with Hodgkin's disease. Correlation of morphologic, immunophenotypic, and molecular genetic findings in 12 cases.The American journal of pathology · 1990Article
- The neo-synovial membrane of patients with active rheumatoid arthritis at resynovectomy. Histomorphological and immunohistological evaluations.Rheumatology international · 1990Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunophenotypic analysis of paraffin-embedded tissues of lymphoproliferative disorders has been facilitated by recent developments of monoclonal antibodies that react with epitopes that survive histologic processing. Leukocyte common antigen (LCA) antibody has made a significant contribution to the immunocytochemical separation of non-Hodgkin's lymphomas from nonlymphoid neoplasms. However, a small percentage of lymphomas, particularly some large cell or immunoblastic B-cell tumors, will not label with LCA antibody. Other antibodies, directed against B lymphocytes, experience problems of specificity and a lack of sensitivity when applied to formalin-fixed specimens. The authors recently investigated a monoclonal antibody (L26) that demonstrates excellent specificity and sensitivity for B lymphocytes, and tumors derived from them, in formalin- and B5-fixed, paraffin-embedded tissue. The avidin-biotin peroxidase complex (ABC) technique was utilized for immunostaining 95 cases of malignant lymphoproliferative disorders and a variety of normal and neoplastic nonlymphoid tissues. When applied to sections of benign lymphoid tissue, the L26 antibody labeled germinal center cells, mantle zone and scattered interfollicular lymphocytes, but not histiocytes or plasma cells. L26 marked 100% (44/44) of the large cell and immunoblastic B-cell lymphomas, along with 1 case of pre-B cell lymphoblastic lymphoma. This included 8 cases that were LCA-negative. None of the T-cell lymphomas or plasma cell tumors studied demonstrated L26 immunostaining. No normal, benign, or neoplastic nonlymphoid tissues examined stained with this antibody. L26 successfully labels B lymphocytes and B-cell lymphomas in routinely processed tissues, often with greater sensitivity and intensity than LCA. This antibody should prove invaluable in the investigation of atypical lymphoid proliferations and the identification of B-cell derived lymphomas, when fresh or frozen tissue is unavailable for analysis.
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