Evidence map›Paper›PMID 33220047›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2021

An Evaluation of Potential Unintended Consequences of a Nicotine Product Standard: A Focus on Drinking History and Outcomes.

Sarah S Dermody, Katelyn M Tessier, Ellen Meier, Mustafa al'Absi, Rachel L Denlinger-Apte, David J Drobes, Joni Jensen, Joseph S Koopmeiners, Lauren R Pacek, Jennifer W Tidey and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Regulatory Approaches and Implementation of Minimally Addictive Combusted Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Sarah S DermodyDepartment of Psychology, Ryerson University, Toronto, ON, Canada.ORCID 0000-0003-4998-6803
Katelyn M TessierMasonic Cancer Center, University of Minnesota, Duluth, MN, USA.
Ellen MeierDepartment of Psychology, University of Wisconsin-Stevens Point, USA.
Mustafa al'AbsiMasonic Cancer Center, University of Minnesota, Duluth, MN, USA.
Rachel L Denlinger-ApteDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-3182-7188
David J DrobesTobacco Research and Intervention Program, Moffitt Cancer Center, Tampa, FL, USA.
Joni JensenMasonic Cancer Center, University of Minnesota, Duluth, MN, USA.
Joseph S KoopmeinersMasonic Cancer Center, University of Minnesota, Duluth, MN, USA.
Lauren R PacekPsychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-1412-1765
Jennifer W TideyDepartment of Behavioral and Social Sciences, Brown University, Providence, RI, USA.
Ryan VandreyDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Eric DonnyDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-3288-9652
Dorothy HatsukamiMasonic Cancer Center, University of Minnesota, Duluth, MN, USA.
University of Minnesota, Duluth · USWake Forest University · USBrown University · USDuke University · USJohns Hopkins University · USMoffitt Cancer Center · USToronto Metropolitan University · CAUniversity of Wisconsin–Stevens Point · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
VERY LOW NICOTINE CIGARETTES IN SMOKERS WITH SCHIZOPHRENIAU54DA031659 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HATSUKAMI, DOROTHY K · 2011 to 2022
$64.7M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Substance Abuse Intervention/Outcome Research TrainingT32DA016184 · NIDA · BROWN UNIVERSITY · PI Damaris J. Rohsenow, JENNIFER W. TIDEY · 2003 to 2026
$6.1M
Cancer Prevention And Control Training Grant (CAPACITY)T32CA122061 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRISTIE L FOLEY, Kathryn Elizabeth Weaver · 2019 to 2026
$2.1M
NCATS NIH HHS UL1 TR002494NCI NIH HHS P30 CA077598NCI NIH HHS T32 CA122061NIDA NIH HHS T32 DA016184NIDA NIH HHS U54 DA031659
6 · The paper itself

Abstract

introductionA nicotine product standard reducing the nicotine content in cigarettes could improve public health by reducing smoking. This study evaluated the potential unintended consequences of a reduced nicotine product standard by examining its effects on (1) smoking behaviors based on drinking history; (2) drinking behavior; and (3) daily associations between smoking and drinking.

methodsAdults who smoke daily (n = 752) in the United States were randomly assigned to smoke very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC; control) cigarettes for 20 weeks. Linear mixed models determined if baseline drinking moderated the effects of VLNC versus NNC cigarettes on Week 20 smoking outcomes. Time-varying effect models estimated the daily association between smoking VLNC cigarettes and drinking outcomes.

resultsHigher baseline alcohol use (vs no use or lower use) was associated with a smaller effect of VLNC on Week 20 urinary total nicotine equivalents (ps < .05). No additional moderation was supported (ps > .05). In the subsample who drank (n = 415), in the VLNC versus NNC condition, daily alcohol use was significantly reduced from Weeks 17 to 20 and odds of binge drinking were significantly reduced from Weeks 9 to 17. By Week 7, in the VLNC cigarette condition (n = 272), smoking no longer predicted alcohol use but remained associated with binge drinking.

conclusionsWe did not support negative unintended consequences of a nicotine product standard. Nicotine reduction in cigarettes generally affected smoking behavior for individuals who do not drink or drink light-to-moderate amounts in similar ways. Extended VLNC cigarette use may improve public health by reducing drinking behavior. IMPLICATIONS: There was no evidence that a VLNC product standard would result in unintended consequences based on drinking history or when considering alcohol outcomes. Specifically, we found that a very low nicotine standard in cigarettes generally reduces smoking outcomes for those who do not drink and those who drink light-to-moderate amounts. Furthermore, an added public health benefit of a very low nicotine standard for cigarettes could be a reduction in alcohol use and binge drinking over time. Finally, smoking VLNC cigarettes may result in a decoupling of the daily associations between smoking and drinking.

Indexed as

Smoking CessationTobacco ProductsAdultHumansNicotineSmokingTobacco SmokingUnited StatesNicotine

Identifiers

PMID33220047
PMCPMC8186422
OpenAlexW3107582085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.