Evidence map›Paper›PMID 33219854›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2021

Impact of the COVID-19 pandemic on cardiovascular mortality and catherization activity during the lockdown in central Germany: an observational study.

Holger M Nef, Albrecht Elsässer, Helge Möllmann, Mohammed Abdel-Hadi, Timm Bauer, Martin Brück, Holger Eggebrecht, Joachim R Ehrlich, Markus W Ferrari, Stephan Fichtlscherer and 23 more

Open access · hybridAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  20. Transcatheter-based aortic valve replacement vs. isolated surgical aortic valve replacement in 2020.Clinical research in cardiology : official journal of the German Cardiac Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 17 institutions in 1 country.

Holger M NefDepartment of Cardiology, Justus Liebig University Giessen, University Hospital Giessen, Medical Clinic I, Klinikstrasse 33, 35392, Giessen, Germany. holger.nef@innere.med.uni-giessen.de.
Albrecht ElsässerDepartment of Cardiology, Klinikum Oldenburg, Oldenburg, Germany.
Helge MöllmannSt.-Johannes-Hospital Klinik Für Innere Medizin I, Dortmund, Germany.
Mohammed Abdel-HadiDepartment of Cardiology, DRK Kliniken Nordhessen, Kassel, Germany.
Timm BauerDepartment of Cardiology, Sana Klinikum Offenbach, Offenbach, Germany.
Martin BrückDepartment of Cardiology, Lahn-Dill-Kliniken, Klinikum Wetzlar, Wetzlar, Germany.
Holger EggebrechtDepartment of Cardiology, Agaplesion Frankfurter Diakonie Kliniken, Frankfurt, Germany.
Joachim R EhrlichDepartment of Cardiology, St. Josefs-Hospital Wiesbaden, Wiesbaden, Germany.
Markus W FerrariDepartment of Cardiology, Helios Dr. Horst Schmidt Kliniken, Wiesbaden, Germany.
Stephan FichtlschererDepartment of Cardiology, Herz-Kreislauf-Zentrum Klinikum Hersfeld-Rotenburg, Rotenburg, Germany.
Ulrich HinkDepartment of Cardiology, Klinikum Frankfurt Höchst, Frankfurt am Main, Germany.
Hans HölschermannDepartment of Cardiology, Hochtaunus-Kliniken, Bad Homburg, Germany.
Rifat KacaporDepartment of Cardiology, Kliniken Des Main-Taunus-Kreises, Bad Soden am Taunus, Germany.
Oliver KoethDepartment of Cardiology, GPR Gesundheits- Und Pflegezentrum Rüsselsheim, Rüsselsheim, Germany.
Serguei KorboukovHessenklinik Stadtkrankenhaus Korbach, Korbach, Germany.
Steffen LamparterDepartment of Cardiology, Diakonie-Krankenhaus Wehrda, Marburg, Germany.
Alexander J LaspoulasDepartment of Cardiology, Justus Liebig University Giessen, University Hospital Giessen, Medical Clinic I, Klinikstrasse 33, 35392, Giessen, Germany.
Ralf LehmannDepartment of Cardiology, Asklepios Kliniken Langen, Langen, Germany.
Christoph LiebetrauDepartment of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany.
Tobias PlückerDepartment of Cardiology, Eichhof-Stiftung Lauterbach, Lauterbach, Germany.
Jörn Pons-KühnemannJustus Liebig University Giessen, Medical Statistics, Institute of Medical Informatics, Giessen, Germany.
Volker SchächingerDepartment of Cardiology, Klinikum Fulda, Fulda, Germany.
Bernhard SchiefferDepartment of Internal Medicine/Cardiology and Angiology, University Hospital of Marburg, Marburg, Germany.
Peter SchottDepartment of Cardiology, Klinikum Werra Meissner GmbH, Eschwege, Germany.
Matthias SchulzeDepartment of Cardiology, Asklepios Schwalm-Eder-Kliniken, Schwalmstadt, Germany.
Claudius TeupeDepartment of Cardiology, Krankenhaus Sachsenhausen, Frankfurt am Main, Germany.
Mariuca Vasa-NicoteraDepartment of Cardiology, University of Frankfurt, Frankfurt, Germany.
Michael WeberDepartment of Cardiology, Kreisklinik Groß-Umstadt, Groß-Umstadt, Germany.
Christoph WeinbrennerDepartment of Cardiology, Klinikum Hanau, Hanau, Germany.
Gerald WernerDepartment of Cardiology, Klinikum Darmstadt, Darmstadt, Germany.
Christian W HammDepartment of Cardiology, Justus Liebig University Giessen, University Hospital Giessen, Medical Clinic I, Klinikstrasse 33, 35392, Giessen, Germany.
Oliver DörrDepartment of Cardiology, Justus Liebig University Giessen, University Hospital Giessen, Medical Clinic I, Klinikstrasse 33, 35392, Giessen, Germany.
CoVCAD –Study Group
Justus-Liebig-Universität Gießen · DEAccadis Hochschule Bad Homburg · DEGoethe University Frankfurt · DEHelios Dr. Horst Schmidt Kliniken Wiesbaden · DEKlinikum Hanau · DEPhilipps University of Marburg · DESana Klinikum Offenbach · DEAgaplesion Frankfurter Diakonie Kliniken · DEAlfried Krupp von Bohlen und Halbach Foundation · DEAsklepios · DEKerckhoff Klinik · DEKlinikum Darmstadt · DEKlinikum Frankfurt Höchst · DEKlinikum Oldenburg · DEKrankenhaus Sachsenhausen · DESt.-Johannes-Hospital Dortmund · DESt. Josefs Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsDuring the COVID-19 pandemic, hospital admissions for cardiac care have declined. However, effects on mortality are unclear. Thus, we sought to evaluate the impact of the lockdown period in central Germany on overall and cardiovascular deaths. Simultaneously we looked at catheterization activities in the same region. METHODS AND

resultsData from 22 of 24 public health-authorities in central Germany were aggregated during the pandemic related lockdown period and compared to the same time period in 2019. Information on the total number of deaths and causes of death, including cardiovascular mortality, were collected. Additionally, we compared rates of hospitalization (n = 5178) for chronic coronary syndrome (CCS), acute coronary syndrome (ACS), and out of hospital cardiac arrest (OHCA) in 26 hospitals in this area. Data on 5,984 deaths occurring between March 23, 2020 and April 26, 2020 were evaluated. In comparison to the reference non-pandemic period in 2019 (deaths: n = 5832), there was a non-significant increase in all-cause mortality of 2.6% [incidence rate ratio (IRR) 1.03, 95% confidence interval (CI) 0.99-1.06; p = 0.16]. Cardiovascular and cardiac mortality increased significantly by 7.6% (IRR 1.08, 95%-CI 1.01-1.14; p = 0.02) and by 11.8% (IRR 1.12, 95%-CI 1.05-1.19; p < 0.001), respectively. During the same period, our data revealed a drop in cardiac catherization procedures.

conclusionDuring the COVID-19-related lockdown a significant increase in cardiovascular mortality was observed in central Germany, whereas catherization activities were reduced. The mechanisms underlying both of these observations should be investigated further in order to better understand the effects of a pandemic-related lockdown and social-distancing restrictions on cardiovascular care and mortality.

Indexed as

COVID-19AgedCardiac CatheterizationCardiovascular DiseasesCause of DeathFemaleGermanyHospitalizationHospital MortalityHumansMaleMiddle AgedPercutaneous Coronary InterventionRisk FactorsTime FactorsAcute coronary syndromeCardiovascular mortalityChronic coronary syndromeCOVID-19SARS-CoV2 pandemic

Identifiers

PMID33219854
PMCPMC7680078
OpenAlexW3099115746

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.