ArticleHuman brain mapping2021
Parahippocampal area three gray matter is reduced in first-episode schizophrenia spectrum: Discovery and replication samples.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.The American journal of psychiatry · 2025Pooled it
- Targeting the Roots of Psychosis: The Role of Aberrant Salience.Pediatric reports · 2025Review
- Measurement of Limbic System Anatomical Volumes in Patients Diagnosed with Schizophrenia Using Vol2brain and Comparison with Healthy Individuals.Medicina (Kaunas, Lithuania) · 2025Article
- Clinical anatomy of the precuneus and pathogenesis of the schizophrenia.Anatomical science international · 2023Review
- Dysconnection and cognition in schizophrenia: A spectral dynamic causal modeling study.Human brain mapping · 2023Article
- Increased cortical structural covariance correlates with anhedonia in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Morphological Abnormalities in Early-Onset Schizophrenia Revealed by Structural Magnetic Resonance Imaging.Biology · 2023Article
- Functional connectivity and gray matter deficits within the auditory attention circuit in first-episode psychosis.Frontiers in psychiatry · 2023Article
- Identification of texture MRI brain abnormalities on first-episode psychosis and clinical high-risk subjects using explainable artificial intelligence.Translational psychiatry · 2022Article
- Altered Coupling of Cerebral Blood Flow and Functional Connectivity Strength in First-Episode Schizophrenia Patients With Auditory Verbal Hallucinations.Frontiers in neuroscience · 2022Article
- Parahippocampal area three gray matter is reduced in first-episode schizophrenia spectrum: Discovery and replication samples.Human brain mapping · 2021Article
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3 authors.
Funding
Abstract
Early course schizophrenia is associated with reduced gray matter. The specific structures affected first and how deficits impact symptoms and cognition remain unresolved. We used the Human Connectome Project multimodal parcellation (HCP-MMP) to precisely identify cortical areas and investigate thickness abnormalities in discovery and replication samples of first-episode schizophrenia spectrum individuals (FESz). In the discovery sample, T1w scans were acquired from 31 FESz and 31 matched healthy controls (HC). Thickness was calculated for 360 regions in Freesurfer. In the replication sample, high-resolution T1w, T2w, and BOLD-rest scans were acquired from 23 FESz and 32 HC and processed with HCP protocols. Thickness was calculated for regions significant in the discovery sample. After FDR correction (q < .05), left and right parahippocampal area 3 (PHA3) were significantly thinner in FESz. In the replication sample, bilateral PHA3 were again thinner in FESz (q < .05). Exploratory correlation analyses revealed left PHA3 was positively associated with hallucinations and right PHA3 was positively associated with processing speed, working memory, and verbal learning. The novel use of the HCP-MMP in two independent FESz samples revealed thinner bilateral PHA3, suggesting this byway between cortical and limbic processing is a critical site of pathology near the emergence of psychosis.
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