Evidence map›Paper›PMID 33219716›Full record

ArticleJournal of veterinary internal medicine2021

Serum interleukin 17 concentrations in dogs with immune-mediated hemolytic anemia.

Benoît Cuq, Shauna L Blois, Christian Bédard, R Darren Wood, Anthony C Abrams-Ogg, Guy Beauchamp, Geoffrey A Wood

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Benoît CuqSmall Animal Clinical Studies, University College Dublin School of Veterinary Medicine, Dublin, Ireland.ORCID https://orcid.org/0000-0002-7707-3625
Shauna L BloisDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0000-0002-4148-4617
Christian BédardDépartement de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, St Hyacinthe, Quebec, Canada.
R Darren WoodDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Anthony C Abrams-OggDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Guy BeauchampDépartement de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, St Hyacinthe, Quebec, Canada.
Geoffrey A WoodDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
University of Guelph · CACegep de Saint Hyacinthe · CAUniversity College Dublin · IE

Funding

OVC Pet Trust Fund 052574
6 · The paper itself

Abstract

backgroundIncreased serum interleukin 17 (IL-17) concentration has been associated with the immunopathogenesis of autoimmune hemolytic anemia in humans. No data are available about IL-17 in immune-mediated hemolytic anemia (IMHA) of dogs.

objectivesMonitor changes in serum IL-17 concentration during the acute stages of IMHA in dogs, compared with results in healthy dogs, and its relationship with outcome. ANIMALS: Thirty-one client-owned dogs with primary IMHA and 27 healthy dogs.

methodsQuantification of serum IL-17 concentration using a commercially available ELISA kit at the time of admission (D0), after 48 hours (D2) and after 96 hours (D4) as compared to concentration in healthy dogs. The IMHA dogs were classified as survivors if discharged from hospital, or nonsurvivors for any cause of in-hospital mortality.

resultsMean serum IL-17 concentration was higher in dogs with IMHA on admission compared with healthy dogs (D0), but this difference was not significant (mean, 19.52 pg/mL vs 10.52 pg/mL, respectively, P = .17). Throughout hospitalization, serum IL-17 concentration significantly decreased in survivors. Serum IL-17 concentration at D0 was not different between survivors and nonsurvivors, but surviving dogs had significantly lower serum IL-17 concentration at D2 and D4 (P = .04 and P = .004, respectively) compared with nonsurviving dogs. No correlation was found between serum IL-17 concentration and serum total bilirubin or lactate concentrations or CBC parameters. CONCLUSION AND CLINICAL IMPORTANCE: Serum IL-17 concentration remained significantly higher in nonsurviving IMHA dogs whereas it significantly decreased during hospitalization in survivors, making serum IL-17 concentration a potential biomarker for severity and response to treatment in IMHA.

Indexed as

Anemia, Hemolytic, AutoimmuneDog DiseasesAnimalsBiomarkersDogsInterleukin-17BiomarkersInterleukin-17autoimmune diseasecaninecytokinesinflammation

Identifiers

PMID33219716
PMCPMC7848375
OpenAlexW3104736163

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.