ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2021
Greater Social Engagement and Greater Gray Matter Microstructural Integrity in Brain Regions Relevant to Dementia.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- A 20-week, randomized controlled trial to determine the efficacy of the Aging Well through Interaction and Scientific Education - Action Plan (AgeWISE-AP) program in older Veterans.BMC geriatrics · 2025Trial
- Social engagement and brain structure-informed cognitive domain trajectories in older adults: The National Health and Aging Trends Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multilayer network analysis of dynamic network reconfiguration in age-related hearing loss: a cross-sectional case-control study.Quantitative imaging in medicine and surgery · 2025Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- The relationship between changes in functional connectivity gradients and cognitive-emotional disorders in sudden sensorineural hearing loss.Brain communications · 2024Article
- Mechanism of the impacts of older adults social participation on their health.Frontiers in public health · 2024Article
- Cardiorespiratory Fitness and Muscular Strength Do Not Predict Social Cognitive Capacity in Older Age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- The Impact of Dance Movement Interventions on Psychological Health in Older Adults without Dementia: A Systematic Review and Meta-Analysis.Brain sciences · 2023Review
- Promoting Successful Cognitive Aging: A Ten-Year Update.Journal of Alzheimer's disease : JAD · 2021Review
- Diffusion Tensor Imaging of the Olfactory System in Older Adults With and Without Hyposmia.Frontiers in aging neuroscience · 2021Article
- Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSocial engagement (SE) may protect against cognitive decline in older adults. We estimate associations of SE with gray matter (GM) microstructure in regions of interest (ROI) relevant to social cognition, among community-dwelling older adults.
methodCross-sectional analysis of 293 Health ABC study participants who underwent 3 Tesla magnetic resonance imaging with diffusion tensor and free from cognitive impairment was conducted. Linear regression models tested associations between SE index (marital status, not living alone, social activities, work, and volunteering) and mean diffusivity (MD) of GM ROIs, adjusted for age, race, gender, and education. Hearing and activities of daily living (ADL) difficulties were tested as confounders. Effect modification by gender was tested with interaction terms and stratification by gender.
resultsHigher SE was significantly related to lower MD (greater GM microstructural integrity) (shown as standardized estimate [p-value]) in left middle frontal gyrus-orbital part: -.168 (.005), left caudate nucleus: -.141 (.02), left temporal pole-middle temporal gyrus: -.136 (.03), right middle frontal gyrus: -.160 (.006), right superior frontal gyrus-orbital part: -.187 (.002), and right middle frontal gyrus-orbital part: -.124 (.04), when adjusted for demographic attributes. Associations were robust to adjustments for hearing or ADL difficulty. There was significant effect modification by gender for some ROIs, with associations only for females. DISCUSSION: SE is related to greater microstructural integrity of specific GM regions relevant to social cognition, that have described roles in dementia. SE may therefore be a useful preventive mechanism against loss of GM integrity in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.