Evidence map›Paper›PMID 33219681›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection After Recovery from Mild Coronavirus Disease 2019.

Jee-Soo Lee, So Yeon Kim, Taek Soo Kim, Ki Ho Hong, Nam-Hee Ryoo, Jaehyeon Lee, Jae Hyeon Park, Sung Im Cho, Man Jin Kim, Young-Gon Kim and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 7 pooled it
2.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 7 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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  4. Reinfection in patients with COVID-19: a systematic review.Global health research and policy · 2022
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  11. A comparison between SARS-CoV-1 and SARS-CoV2: an update on current COVID-19 vaccines.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Jee-Soo LeeDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
So Yeon KimDepartment of Laboratory Medicine, National Medical Center, Seoul, South Korea.
Taek Soo KimDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Ki Ho HongDepartment of Laboratory Medicine, Seoul Medical Center, Seoul, South Korea.
Nam-Hee RyooDepartment of Laboratory Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
Jaehyeon LeeDepartment of Laboratory Medicine, Jeonbuk National University Medical School and Hospital, Jeonju, South Korea.
Jae Hyeon ParkDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Sung Im ChoDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Man Jin KimDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Young-Gon KimDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Boram KimDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Ho Seob ShinDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Hyeon Sae OhDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Myoung-Seock SeoDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Tae-Rin GwonDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Yeonjae KimDepartment of Infectious Disease, National Medical Center, Seoul, South Korea.
Jun-Sun ParkResearch Institute of Public Health, National Medical Center, Seoul, South Korea.
Bum Sik ChinDepartment of Infectious Disease, National Medical Center, Seoul, South Korea.
Wan Beom ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Sung Sup ParkDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Moon-Woo SeongDepartment of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Seoul National University Hospital · KRNational Medical Center · KRJeonbuk National University · KRJeonbuk National University Hospital · KRKeimyung University · KRSeoul Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPositive results from real-time reverse-transcription polymerase chain reaction (rRT-PCR) in recovered patients raise concern that patients who recover from coronavirus disease 2019 (COVID-19) may be at risk of reinfection. Currently, however, evidence that supports reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not been reported.

methodsWe conducted whole-genome sequencing of the viral RNA from clinical specimens at the initial infection and at the positive retest from 6 patients who recovered from COVID-19 and retested positive for SARS-CoV-2 via rRT-PCR after recovery. A total of 13 viral RNAs from the patients' respiratory specimens were consecutively obtained, which enabled us to characterize the difference in viral genomes between initial infection and positive retest.

resultsAt the time of the positive retest, we were able to acquire a complete genome sequence from patient 1, a 21-year-old previously healthy woman. In this patient, through the phylogenetic analysis, we confirmed that the viral RNA of positive retest was clustered into a subgroup distinct from that of the initial infection, suggesting that there was a reinfection of SARS-CoV-2 with a subtype that was different from that of the primary strain. The spike protein D614G substitution that defines the clade "G" emerged in reinfection, while mutations that characterize the clade "V" (ie, nsp6 L37F and ORF3a G251V) were present at initial infection.

conclusionsReinfection with a genetically distinct SARS-CoV-2 strain may occur in an immunocompetent patient shortly after recovery from mild COVID-19. SARS-CoV-2 infection may not confer immunity against a different SARS-CoV-2 strain.

Indexed as

COVID-19SARS-CoV-2AdultFemaleHumansPhylogenyReinfectionRNA, ViralYoung AdultRNA, ViralCOVID-19reinfectionSARS-CoV-2whole-genome sequencing

Identifiers

PMID33219681
PMCPMC7890673
OpenAlexW3099037064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.