Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021
Adverse childhood experiences (ACEs) and medically traumatic events (TEs) in adolescents and young adults (AYAs) with cancer: a report from the Promoting Resilience in Stress Management (PRISM) randomized controlled trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Systematic review and meta-analysis of psychological interventions for depression symptoms in young people with long-term physical health conditions.Journal of pediatric psychology · 2025Pooled it
- Effect of nurse-led intervention programs based on spiritual care on the resilience and death anxiety in parents of children and adolescents with cancer, a randomized clinical trial.BMC psychology · 2025Trial
- Assessment of the Promoting Resilience in Stress Management Intervention for Adolescent and Young Adult Survivors of Cancer at 2 Years: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2021Trial
- Feasibility of an Online Resilience Program for Mothers With Adverse Childhood Experiences.Research in nursing & health · 2026Article
- Exploring the link between adverse childhood experiences and cancer development - insights and intervention recommendations from a scoping review.Npj mental health research · 2025Article
- Cognitive and affective links between childhood adversity and psychological adjustment in emerging adults with chronic medical conditions.Journal of pediatric psychology · 2024Article
- Review
- Article
- Developmental Neuroendocrinology of Early-Life Stress: Impact on Child Development and Behavior.Current neuropharmacology · 2024Review
- How nurses can promote resilience among adolescents receiving active cancer treatment: A scoping review.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2024Article
- Article
- Palliative Care Interventions Among Adolescents and Young Adults with Serious Illness: A Scoping Review.Clinical practice in pediatric psychology · 2023Article
- Commentary: Posttraumatic Growth Following Pediatric Solid Organ Transplantation: Making Meaning Out of the Gift of Life.Journal of pediatric psychology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveIn adolescents and young adults (AYAs) with cancer, we examined (1) the distribution and type of traumatic events (TEs) experienced prior to baseline assessment and (2) how a resilience intervention, Promoting Resilience in Stress Management (PRISM), impacted changes in patient-reported outcomes (PROs) for AYAs with and without TEs.
methodsAYAs (12-25 years) within 1-10 weeks of diagnosis of new malignancy or ever diagnosed with advanced cancer were enrolled and randomly assigned to usual care (UC) with or without PRISM. To assess TEs, we screened medical records for traditionally defined adverse childhood experiences (ACEs) and medical traumatic events. Age-validated PROs assessed resilience, benefit-finding, hope, generic health-related quality of life (QoL), cancer-specific QoL, depression, and anxiety at enrollment and 6 months later. We calculated effect sizes (Cohen's d) for PRISM vs. UC effect on PRO score change at 6 months for 1+ TEs and 0 TE groups.
resultsNinety-two AYAs enrolled and completed baseline surveys (44-UC, 48-PRISM; N = 74 at 6 months, 38-UC, 36-PRISM); 60% experienced 1+ TEs. PROs at baseline were similar across groups. PRISM's effect on score change was greater (Cohen's d ≥ 0.5) for the 1+ TE group on domains of benefit-finding and hope; and similar (d < 0.5) on domains of resilience, depression, anxiety, and both generic and cancer-specific QoL.
conclusionsIn AYAs with cancer, TEs occurred at similar rates as the general population. PRISM may be particularly helpful for improving benefit-finding and hope for those who have experienced TEs.
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