ArticleMolecular biology and evolution2020
Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.
Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Genotypic and Phenotypic Diversity of Maudiozyma humilis: The Multiple Evolutionary Trajectories of a Domesticated Yeast.Genome biology and evolution · 2026Article
- Contrasting mutation patterns in haploid and diploid cells from two yeast species.bioRxiv : the preprint server for biology · 2025Article
- Rise and Fall ofJournal of fungi (Basel, Switzerland) · 2025Article
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- Genome-wide assessment of genetic diversity and transcript variations in 17 accessions of the model diatomISME communications · 2024Article
- Article
- Inflammation and tumor microenvironment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Review
- Loss of Heterozygosity and Its Importance in Evolution.Journal of molecular evolution · 2023Review
- Silver nanoparticles elevate mutagenesis of eukaryotic genomes.G3 (Bethesda, Md.) · 2023Article
- Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations.Molecular biology and evolution · 2022Article
- Recent insights into the evolution of mutation rates in yeast.Current opinion in genetics & development · 2022Review
- From Genome Variation to Molecular Mechanisms: What we Have Learned From Yeast Mitochondrial Genomes?Frontiers in microbiology · 2022Review
- Heterogeneous Mutation Rates and Spectra in Yeast Hybrids.Genome biology and evolution · 2021Article
- Sex without crossing over in the yeast Saccharomycodes ludwigii.Genome biology · 2021Article
- Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus.Nature communications · 2021Article
- Genetic and Phenotypic Diversities in Experimental Populations of Diploid Inter-Lineage Hybrids in the Human PathogenicMicroorganisms · 2021Article
- Loss of heterozygosity results in rapid but variable genome homogenization across yeast genetic backgrounds.eLife · 2021Article
- The insect-killing bacteriumMarine life science & technology · 2021Article
- Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Mutation and recombination are the primary sources of genetic variation. To better understand the evolution of genetic variation, it is crucial to comprehensively investigate the processes involving mutation accumulation and recombination. In this study, we performed mutation accumulation experiments on four heterozygous diploid yeast species in the Saccharomycodaceae family to determine spontaneous mutation rates, mutation spectra, and losses of heterozygosity (LOH). We observed substantial variation in mutation rates and mutation spectra. We also observed high LOH rates (1.65-11.07×10-6 events per heterozygous site per cell division). Biases in spontaneous mutation and LOH together with selection ultimately shape the variable genome-wide nucleotide landscape in yeast species.
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