SynthesisProstate cancer and prostatic diseases2021
A systematic review and meta-analysis of the diagnostic accuracy of biparametric prostate MRI for prostate cancer in men at risk.
Synthesis in Prostate cancer and prostatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05384535 (Utility of Biparametric MRI), which is not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Head-to-head comparison of diagnostic test accuracy between biparametric and multiparametric MRI: an updated systematic review and bivariate meta-analysis.Prostate cancer and prostatic diseases · 2025Pooled it
- Diagnostic Ability of Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Prostate Cancer and Clinically Significant Prostate Cancer in Equivocal Lesions: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Critical appraisal of artificial intelligence studies for prostate cancer detection on MRI.European radiology · 2026Article
- Clinical significance of MRI PI-RADS 3 lesions upgraded by dynamic contrast enhancement: the "PI-RADS 3 + 1" subgroup.International urology and nephrology · 2026Article
- Semi-supervised learning in prostate MRI tumor detection approaches fully supervised performance on external validation.European radiology · 2026Article
- Implementation of a biparametric prostate MRI protocol with a recall system for intravenous contrast: an analysis of recall rates and comparison of PI-RADS category distribution.Abdominal radiology (New York) · 2026Article
- Artificial Intelligence in Prostate MRI: Addressing Current Limitations Through Emerging Technologies.Journal of magnetic resonance imaging : JMRI · 2026Review
- Diagnostic performance of biparametric versus multiparametric MRI for prostate cancer: a noninferiority, confirmatory observer study.Frontiers in oncology · 2026Article
- A commentary on "Abbreviated biparametric versus multiparametric MRI for the detection of clinically significant prostate cancer in treatment-naïve patients: a diagnostic test accuracy systematic review and meta-analysis".International journal of surgery (London, England) · 2025Article
- Multitracer comparison of gold standard PSMA-PET/CT withEuropean journal of nuclear medicine and molecular imaging · 2025Article
- On-table monitoring of prostate MRI could enable tailored utilisation of gadolinium contrast.European radiology · 2025Observational
- Enhanced ISUP grade prediction in prostate cancer using multi-center radiomics data.Abdominal radiology (New York) · 2025Article
- Improving risk stratification of PI-RADS 3 + 1 lesions of the peripheral zone: expert lexicon of terms, multi-reader performance and contribution of artificial intelligence.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Negative Predictive Value of a Prostate MRI in Black Men: Implications for Biopsy Decision-Making.The Journal of urology · 2025Article
- Long-Term Risk of Clinically Significant Prostate Cancer in Biopsy-Negative Patients With Baseline Biparametric Prostate MRI.Journal of magnetic resonance imaging : JMRI · 2025Article
- Ultra-fast biparametric MRI in prostate cancer assessment: Diagnostic performance and image quality compared to conventional multiparametric MRI.European journal of radiology open · 2025Article
- The Accuracy of Biparametric Prostate MRI in the Pathway of Patients With Prostate Cancer.Cureus · 2025Article
- Biparametric MRI-based radiomics for prediction of clinically significant prostate cancer of PI-RADS category 3 lesions.BMC cancer · 2025Article
- Evaluating Biparametric Versus Multiparametric Magnetic Resonance Imaging for Diagnosing Clinically Significant Prostate Cancer: An International, Paired, Noninferiority, Confirmatory Observer Study.European urology · 2025Article
- Analysis of the Diagnostic Efficacy and Clinical Utility of Multiparametric MRI in Prostate Cancer Diagnosis.Cancer management and research · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
introductionMultiparametric magnetic resonance imaging (mpMRI), the use of three multiple imaging sequences, typically T2-weighted, diffusion weighted (DWI) and dynamic contrast enhanced (DCE) images, has a high sensitivity and specificity for detecting significant cancer. Current guidance now recommends its use prior to biopsy. However, the impact of DCE is currently under debate regarding test accuracy. Biparametric MRI (bpMRI), using only T2 and DWI has been proposed as a viable alternative. We conducted a contemporary systematic review and meta-analysis to further examine the diagnostic performance of bpMRI in the diagnosis of any and clinically significant prostate cancer.
methodsA systematic review of the literature from 01/01/2017 to 06/07/2019 was performed by two independent reviewers using predefined search criteria. The index test was biparametric MRI and the reference standard whole-mount prostatectomy or prostate biopsy. Quality of included studies was assessed by the QUADAS-2 tool. Statistical analysis included pooled diagnostic performance (sensitivity; specificity; AUC), meta-regression of possible covariates and head-to-head comparisons of bpMRI and mpMRI where both were performed in the same study.
resultsForty-four articles were included in the analysis. The pooled sensitivity for any cancer detection was 0.84 (95% CI, 0.80-0.88), specificity 0.75 (95% CI, 0.68-0.81) for bpMRI. The summary ROC curve yielded a high AUC value (AUC = 0.86). The pooled sensitivity for clinically significant prostate cancer was 0.87 (95% CI, 0.78-0.93), specificity 0.72 (95% CI, 0.56-0.84) and the AUC value was 0.87. Meta-regression analysis revealed no difference in the pooled diagnostic estimates between bpMRI and mpMRI.
conclusionsThis meta-analysis on contemporary studies shows that bpMRI offers comparable test accuracies to mpMRI in detecting prostate cancer. These data are broadly supportive of the bpMRI approach but heterogeneity does not allow definitive recommendations to be made. There is a need for prospective multicentre studies of bpMRI in biopsy naïve men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.