Evidence map›Paper›PMID 33219340›Full record

ArticleBone marrow transplantation2021

Stem cell donor registry activities during the COVID-19 pandemic: a field report by DKMS.

Thilo Mengling, Gabi Rall, Stefanie N Bernas, Nadia Astreou, Sandra Bochert, Torben Boelk, Deborah Buk, Konstanze Burkard, Dennis Endert, Katrin Gnant and 17 more

Open access · hybridAbstract read
In one paragraph

Article in Bone marrow transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 2 institutions in 1 country.

Thilo MenglingDKMS, Tübingen, Germany. mengling@dkms.de.ORCID http://orcid.org/0000-0002-1349-1094
Gabi RallDKMS, Tübingen, Germany.
Stefanie N BernasDKMS, Tübingen, Germany.ORCID http://orcid.org/0000-0002-9700-6710
Nadia AstreouDKMS, Tübingen, Germany.
Sandra BochertDKMS, Tübingen, Germany.
Torben BoelkDKMS, Tübingen, Germany.
Deborah BukDKMS, Tübingen, Germany.
Konstanze BurkardDKMS, Tübingen, Germany.
Dennis EndertDKMS, Tübingen, Germany.
Katrin GnantDKMS, Tübingen, Germany.
Sabine HildebrandDKMS, Tübingen, Germany.
Hatice KöksaldiDKMS, Tübingen, Germany.
Isabelle PetitDKMS, Tübingen, Germany.
Jürgen SauterDKMS, Tübingen, Germany.ORCID http://orcid.org/0000-0001-8485-2945
Susanne SeitzDKMS, Tübingen, Germany.
Julia StolzeDKMS, Tübingen, Germany.
Karin WeberDKMS, Tübingen, Germany.
Maren WeberDKMS, Tübingen, Germany.
Vinzenz LangeDKMS Life Science Lab, Dresden, Germany.ORCID http://orcid.org/0000-0002-6442-9573
Julia PingelDKMS, Tübingen, Germany.
Alexander PlatzDKMS Life Science Lab, Dresden, Germany.
Thomas SchäferDKMS Life Science Lab, Dresden, Germany.
Johannes ScheteligDKMS, Clinical Trials Unit, Dresden, Germany.ORCID http://orcid.org/0000-0002-2780-2981
Edith WienandDKMS, Tübingen, Germany.
Sirko GeistDKMS, Tübingen, Germany.
Elke NeujahrDKMS, Tübingen, Germany.
Alexander H SchmidtDKMS, Tübingen, Germany.
Deutsche Knochenmarkspenderdatei · DEUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has serious implications also for patients with other diseases. Here, we describe the effects of the pandemic on unrelated hematopoietic stem cell donation and transplantation from the perspective of DKMS, a large international donor registry. Especially, we cover the development of PBSC and bone marrow collection figures, donor management including Health and Availability Check (HAC), transport and cryopreservation of stem cell products, donor recruitment and business continuity measures. The total number of stem cell products provided declined by around 15% during the crisis with a particularly strong decrease in bone marrow products. We modified donor management processes to ensure donor and product safety. HAC instead of confirmatory typing was helpful especially in countries with strict lockdowns. New transport modes were developed so that stem cell products could be safely delivered despite COVID-19-related travel restrictions. Cryopreservation of stem cell products became the new temporary standard during the pandemic to minimize risks related to transport logistics and donor availability. However, many products from unrelated donors will never be transfused. DKMS discontinued public offline donor recruitment, leading to a 40% decline in new donors during the crisis. Most DKMS employees worked from home to ensure business continuity during the crisis.

Indexed as

COVID-19Hematopoietic Stem CellsRegistriesTissue DonorsCommunicable Disease ControlCryopreservationHumansPandemics

Identifiers

PMID33219340
PMCPMC7677905
OpenAlexW3098306838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.