ReviewNature reviews. Clinical oncology2021
Rising incidence of early-onset colorectal cancer - a call to action.
Review in Nature reviews. Clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06342401 (Development and Validation fo an Exosome-Based and Machine Learning Powered Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer), which is not on this map. Cited by 464 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development and Validation fo an Exosome-Based and Machine Learning Powered Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer
Who cites it
464 citing papers in PubMed, 3 syntheses or guidelines pooled it, 656 citations in OpenAlex.
- Early versus late closure of protective ileostomy after rectal cancer surgery.International journal of colorectal disease · 2026Pooled it
- At what age should people with obesity start colorectal cancer screening?International journal of cancer · 2026Pooled it
- Clinicopathological characteristics and biomarker alterations in early-onset vs. late-onset colorectal cancer: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Pooled it
- Clinical Efficacy of Real-Time Artificial Intelligence-Assisted Colonoscopy in Colorectal Polyp Detection: A Prospective Multicenter Randomized Controlled Trial.Gut and liver · 2026Trial
- Short-course versus long-course neoadjuvant chemoradiotherapy in patients with rectal cancer: long-term results of a randomized controlled trial.International journal of colorectal disease · 2025Trial
- Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.Gut microbes · 2026Review
- A screening-threshold-oriented framework reveals threshold-adjacent redistribution of global colorectal cancer burden: an analysis of GBD 2023.Annals of medicine · 2026Article
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Colorectal Cancer in Younger and Elderly Patients: A Real-World Analysis from the Modena Cancer Center.Cancers · 2026Article
- Preoperative Laboratory, Imaging, and Risk Assessment Before Elective Colorectal Cancer Resection: What the Clinician Must Remember.Journal of clinical medicine · 2026Review
- Closing the Diagnostic Gap in Early-Onset Colorectal Cancer: Red-Flag Symptoms, Screening, and Inherited Risk.Cancers · 2026Review
- Review
- The change in epidemiological characteristics and utilization of health services for the diagnosis and treatment of colorectal cancer: A hospital-based retrospective survey.Clinics (Sao Paulo, Brazil) · 2026Article
- Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer.Nature genetics · 2026Article
- Association between metabolic dysfunction-associated steatotic liver disease and risk of early-onset advanced colorectal neoplasia: a systematic review and meta-analysis.Journal of gastrointestinal oncology · 2026Article
- Evolution of birth-cohort patterns in lifestyle-associated cancer mortality across high-income countries.International journal of epidemiology · 2026Article
- Clinicopathological Characteristics of Colorectal Neoplasia in Adults Younger than 50 Years: A Real-World Single-Center Study.Journal of clinical medicine · 2026Article
- Genomic Landscape of Early-Onset Colorectal Cancer: A Comparative Analysis With Average-Onset Metastatic Colorectal Cancer in a Real-World NGS Cohort.JCO precision oncology · 2026Article
- The efficacy of colorectal cancer screening: a systematic review and meta-analysis.Preventive medicine reports · 2026Review
- The Changing Face of Gastrointestinal Cancer Mortality: Trends and Divide by Age and Geography.Annals of surgical oncology · 2026Article
404 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
The incidence of early-onset colorectal cancer (CRC), which occurs in individuals <50 years of age, has been increasing worldwide and particularly in high-income countries. The reasons for this increase remain unknown but plausible hypotheses include greater exposure to potential risk factors, such as a Western-style diet, obesity, physical inactivity and antibiotic use, especially during the early prenatal to adolescent periods of life. These exposures can not only cause genetic and epigenetic alterations in colorectal epithelial cells but also affect the gut microbiota and host immunity. Early-onset CRCs have differential clinical, pathological and molecular features compared with later-onset CRCs. Certain existing resources can be utilized to elucidate the aetiology of early-onset CRC and inform the development of effective prevention, early detection and therapeutic strategies; however, additional life-course cohort studies spanning childhood and young adulthood, integrated with prospective biospecimen collections, omics biomarker analyses and a molecular pathological epidemiology approach, are needed to better understand and manage this disease entity. In this Perspective, we summarize our current understanding of early-onset CRC and discuss how we should strategize future research to improve its prevention and clinical management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.