ArticleScientific reports2020
Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Constipation is associated with an increased risk of depression: A systematic review and meta-analysis of observational studies.Translational psychiatry · 2026Pooled it
- Altered cortical thickness in type 2 diabetes mellitus patients revealed by coordinate-based meta-analysis.BMC endocrine disorders · 2026Pooled it
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging.Frontiers in neurology · 2022Pooled it
- Home-based transcutaneous auricular vagus nerve stimulation (taVNS) improves motor and non-motor symptoms by improving autonomic and brain functions in patients with Parkinson's disease: A randomized clinical trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Volumetric analysis of the damage and response of non-invasive brain stimulation in patients with spatial neglect after stroke: a subgroup analysis of the ELETRON trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Trial
- Exploring the capabilities of repetitive transcranial magnetic stimulation in major depressive disorder: Dynamic causal modeling of the neural network.Translational psychiatry · 2025Article
- Reward Network Activations of Win Versus Loss in a Monetary Gambling Task.Behavioral sciences (Basel, Switzerland) · 2025Article
- An objective quantitative diagnosis of depression using a local-to-global multimodal fusion graph neural network.Patterns (New York, N.Y.) · 2024Article
- Frequency specific alterations of the degree centrality in patients with acute basal ganglia ischemic stroke: a resting-state fMRI study.Brain imaging and behavior · 2024Article
- Neural activation during natural speech and rests in patients with schizophrenia and schizophrenia spectrum disorders-an fMRI pilot trial.Frontiers in psychiatry · 2024Article
- Abnormal Functional Connectivity Intra- and Inter-Network in Resting-State Brain Networks of Patients with Toothache.Journal of pain research · 2024Article
- Altered Resting-State Brain Activity and Functional Connectivity in Post-Stroke Apathy: An fMRI Study.Brain sciences · 2023Article
- Individual brain regulation as learned via neurofeedback is related to affective changes in adolescents with autism spectrum disorder.Child and adolescent psychiatry and mental health · 2023Article
- Neuroanatomy of post-stroke depression: the association between symptom clusters and lesion location.Brain communications · 2023Article
- Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction.Frontiers in molecular neuroscience · 2023Article
- Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras.Frontiers in human neuroscience · 2023Article
- Artificially-reconstructed brain images with stroke lesions from non-imaging data: modeling in categorized patients based on lesion occurrence and sparsity.Scientific reports · 2022Article
- Association of Infarct Topography and Outcome After Endovascular Thrombectomy in Patients With Acute Ischemic Stroke.Neurology · 2022Article
- Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke survivors majorly suffered from post-stroke depression (PSD). The PSD diagnosis is commonly performed based on the clinical cut-off for psychometric inventories. However, we hypothesized that PSD involves spectrum symptoms (e.g., apathy, depression, anxiety, and stress domains) and severity levels. Therefore, instead of using the clinical cut-off, we suggested a data-driven analysis to interpret patient spectrum conditions. The patients' psychological conditions were categorized in an unsupervised manner using the k-means clustering method, and the relationships between psychological conditions and quantitative lesion degrees were evaluated. This study involved one hundred sixty-five patient data; all patients were able to understand and perform self-rating psychological conditions (i.e., no aphasia). Four severity levels-low, low-to-moderate, moderate-to-high, and high-were observed for each combination of two psychological domains. Patients with worse conditions showed the significantly greater lesion degree at the right Rolandic operculum (part of Brodmann area 43). The dissimilarities between stress and other domains were also suggested. Patients with high stress were specifically associated with lesions in the left thalamus. Impaired emotion processing and stress-affected functions have been frequently related to those lesion regions. Those lesions were also robust and localized, suggesting the possibility of an objective for predicting psychological conditions from brain lesions.
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