Evidence map›Paper›PMID 33219259›Full record

ArticleScientific reports2020

Cholesteryl ester levels are elevated in the caudate and putamen of Huntington's disease patients.

Gabrielle R Phillips, Sarah E Hancock, Simon H J Brown, Andrew M Jenner, Fabian Kreilaus, Kelly A Newell, Todd W Mitchell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

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  12. Insulin Resistance Is a Modifying Factor for Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Gabrielle R PhillipsIllawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.
Sarah E HancockSchool of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
Simon H J BrownIllawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.
Andrew M JennerBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, 2052, Australia.
Fabian KreilausSchool of Medicine, Western Sydney University, Sydney, NSW, 2560, Australia.
Kelly A NewellIllawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.
Todd W MitchellIllawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia. toddm@uow.edu.au.
Illawarra Health and Medical Research Institute · AUUniversity of Wollongong · AUUniversity of Sydney · AUUNSW Sydney · AUWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is an autosomal dominant neurodegenerative illness caused by a mutation in the huntingtin gene (HTT) and subsequent protein (mhtt), to which the brain shows a region-specific vulnerability. Disturbances in neural cholesterol metabolism are established in HD human, murine and cell studies; however, cholesteryl esters (CE), which store and transport cholesterol in the brain, have not been investigated in human studies. This study aimed to identify region-specific alterations in the concentrations of CE in HD. The Victorian Brain Bank provided post-mortem tissue from 13 HD subjects and 13 age and sex-matched controls. Lipids were extracted from the caudate, putamen and cerebellum, and CE were quantified using targeted mass spectrometry. ACAT 1 protein expression was measured by western blot. CE concentrations were elevated in HD caudate and putamen compared to controls, with the elevation more pronounced in the caudate. No differences in the expression of ACAT1 were identified in the striatum. No remarkable differences in CE were detected in HD cerebellum. The striatal region-specific differences in CE profiles indicate functional subareas of lipid disturbance in HD. The increased CE concentration may have been induced as a compensatory mechanism to reduce cholesterol accumulation.

Indexed as

Acetyl-CoA C-AcetyltransferaseAgedAged, 80 and overAnimalsCase-Control StudiesCaudate NucleusCerebellumCholesterol EstersFemaleHumansHuntington DiseaseMaleMass SpectrometryMiceMiddle AgedPutamenACAT1 protein, humanAcetyl-CoA C-AcetyltransferaseCholesterol Esters

Identifiers

PMID33219259
PMCPMC7680097
OpenAlexW3102326744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.