ArticleNature communications2020
Dominant subtype switch in avian influenza viruses during 2016-2019 in China.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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114citing papers in PubMed
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114 citing papers in PubMed, 182 citations in OpenAlex.
- Genetically engineered M13 phage-mediated H9N2 DNA vaccine with enhanced mucosal and systemic immune responses in mice.Drug delivery · 2026Article
- Genetic evolution, phylodynamics, geographic spread of H9N2 avian influenza viruses in China from 2014 to 2025: an increasing potential zoonotic risk.Emerging microbes & infections · 2026Article
- Spatiotemporal distribution trends and driving factors of avian influenza in poultry in China.One health (Amsterdam, Netherlands) · 2026Article
- A new clade of H9N2 avian influenza virus circulating in Laos.Emerging microbes & infections · 2026Article
- A bivalent inactivated influenza vaccine incorporating epitope-optimized surface proteins confers cross-protective immunity against H9N2 influenza virus.Emerging microbes & infections · 2026Article
- A neuraminidase-targeting nanobody as a therapeutic candidate against influenza A and B viruses.Journal of virology · 2026Article
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- Development and evaluation of a recombinant bivalent HVT-vectored vaccine candidate against H9N2 avian influenza virus and fowl adenovirus serotype 4.Poultry science · 2026Article
- Surveillance and cross-species transmission assessment of H3NX avian influenza viruses isolated in Guangdong province, China from 2023 to 2025.Poultry science · 2026Article
- Epidemiological and Virological Characteristics of H9N2 Avian Influenza Virus in Jiangsu Province, China, 2024.Viruses · 2026Article
- Dominant HA motif 131/132-NT shapes the phenotype of avian H9N2 influenza virus by modulating agglutination property, receptor specificity and infectivity in animals.Virologica Sinica · 2026Article
- Article
- Genetic and biological characterization of H9N2 avian influenza viruses isolated from swine in China.BMC veterinary research · 2026Article
- Emergence of a novel H4N6 avian influenza virus with mammalian adaptation isolated from migratory birds in Zhejiang Province, China, 2024.Virologica Sinica · 2026Article
- Genetic evolution and pathogenicity analysis of two natural recombinant isolates of avian influenza.Poultry science · 2026Article
- HVT-based multiepitope vaccine administered subcutaneously or in ovo boosts protection of inactivated H9N2 vaccine against heterologous virus.Virologica Sinica · 2026Article
- Comparative and predictive analysis of avian influenza in live bird markets of the Poyang Lake region: a long-term monitoring study.Virology journal · 2026Article
- A cross-sectional study of avian influenza virus in poultry markets of Guangdong China, 2025.Frontiers in cellular and infection microbiology · 2026Article
- Environmental circulation of multiple avian influenza subtypes and potential association with human infections in central China.Frontiers in cellular and infection microbiology · 2026Article
- Isoleucine at position 137 of haemagglutinin acts as a mammalian adaptation marker of H9N2 avian influenza virus.Emerging microbes & infections · 2025Article
54 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors at 17 institutions in 4 countries.
Yuhai BiCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China. beeyh@im.ac.cn.ORCID 0000-0002-5595-363X
Juan LiKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, 271016, Taian, China.ORCID 0000-0001-9628-4850
Shanqin LiUniversity of Chinese Academy of Sciences, 101408, Beijing, China.
Guanghua FuInstitute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, 350013, Fuzhou, China.
Tao JinChina National Genebank-Shenzhen, BGI-Shenzhen, 518083, Shenzhen, China.ORCID 0000-0002-9620-1688
Cheng ZhangCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.
Yongchun YangZhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, 311300, Hangzhou, China.
Zhenghai MaCollege of Life Science and Technology, Xinjiang University, 830046, Urumchi, China.
Wenxia TianCollege of Animal Science and Veterinary Medicine, Shanxi Agricultural University, 030801, Taigu, China.ORCID 0000-0001-6018-5180
Jida LiInstitute of Zoonosis, College of Public Hygiene, Zunyi Medical University, 563003, Zunyi, China.
Shuqi XiaoCollege of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
Liqiang LiChina National Genebank-Shenzhen, BGI-Shenzhen, 518083, Shenzhen, China.
Renfu YinDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, 130062, Jilin, China.ORCID 0000-0001-7431-2523
Yi ZhangInstitute of Zoonosis, College of Public Hygiene, Zunyi Medical University, 563003, Zunyi, China.
Lixin WangSchool of Basic Medicine and Life Science, Hainan Medical University, 571101, Haikou, China.
Yantao QinDiqing Tibetan Autonomous Prefecture Centers for Disease Control and Prevention, 674400, Shangri-la, China.
Zhongzi YaoCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, CASCIRE, Chinese Academy of Sciences, 430071, Wuhan, China.
Fanyu MengKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, 271016, Taian, China.
Dongfang HuCollege of Animal Science and Technology, Henan Institute of Science and Technology, 453003, Xinxiang, China.
Delong LiCollege of Animal Science, Southwest University, 402460, Chongqing, China.
Gary WongInstitut Pasteur of Shanghai, Chinese Academy of Sciences, 200031, Shanghai, China.
Fei LiuCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.
Na LvCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.
Liang WangCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.
Lifeng FuCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.ORCID 0000-0003-0431-5424
Yang YangUniversity of Chinese Academy of Sciences, 101408, Beijing, China.
Yun PengUniversity of Chinese Academy of Sciences, 101408, Beijing, China.
Jinmin MaChina National Genebank-Shenzhen, BGI-Shenzhen, 518083, Shenzhen, China.ORCID 0000-0002-7993-7001
Kirill SharshovFederal Research Center of Fundamental and Translational Medicine, Federal State Budget Scientific Institution, Siberian Branch of Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russia, 630090.
Alexander ShestopalovFederal Research Center of Fundamental and Translational Medicine, Federal State Budget Scientific Institution, Siberian Branch of Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russia, 630090.
Marina GulyaevaFederal Research Center of Fundamental and Translational Medicine, Federal State Budget Scientific Institution, Siberian Branch of Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russia, 630090.ORCID 0000-0003-3945-5339
George F GaoCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.ORCID 0000-0002-3869-615X
Jianjun ChenCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, CASCIRE, Chinese Academy of Sciences, 430071, Wuhan, China.ORCID 0000-0002-2966-2388
Yi ShiCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.ORCID 0000-0002-3053-2687
William J LiuNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), 102206, Beijing, China.ORCID 0000-0003-3605-4070
Dong ChuGeneral Station for Surveillance of Wildlife-borne Infectious Diseases, State Forestry and Grassland Administration, 110034, Shenyang, Liaoning Province, PR China.
Yu HuangInstitute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, 350013, Fuzhou, China.
Yingxia LiuShenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, 518112, Shenzhen, China.
Lei LiuShenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, 518112, Shenzhen, China.
Wenjun LiuCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID, Chinese Academy of Sciences, 100101, Beijing, China.
Quanjiao ChenCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, CASCIRE, Chinese Academy of Sciences, 430071, Wuhan, China. chenqj@wh.iov.cn.
Weifeng ShiKey Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, 271016, Taian, China. shiwf@ioz.ac.cn.ORCID 0000-0002-8717-2942
Chinese Academy of Sciences · CNChina National GeneBank · CNChinese Center For Disease Control and Prevention · CNRussian Academy of Sciences · RUZunyi Medical University · CNFujian Academy of Agricultural Sciences · CNShandong First Medical University · CNSouthern University of Science and Technology · CNUniversity of Chinese Academy of Sciences · CNZhejiang A & F University · CNHenan Institute of Science and Technology · CNJilin University · CNNorthwest A&F University · CNShanxi Agricultural University · CNSouthwest University · CNState Forestry and Grassland Administration · CNXinjiang University · CN
Funding
Public Health Epidemiology of Influenza Virus Infection and Control in ChinaU01IP001106 · IP · CHINESE CTR-DISEASE CONTROL/PREVENTION · PI CHEN, HONG · 2018 to 2022
$3.5MACL HHS U01IP001106NCIRD CDC HHS U01 IP001106
Abstract
We have surveyed avian influenza virus (AIV) genomes from live poultry markets within China since 2014. Here we present a total of 16,091 samples that were collected from May 2016 to February 2019 in 23 provinces and municipalities in China. We identify 2048 AIV-positive samples and perform next generation sequencing. AIV-positive rates (12.73%) from samples had decreased substantially since 2016, compared to that during 2014-2016 (26.90%). Additionally, H9N2 has replaced H5N6 and H7N9 as the dominant AIV subtype in both chickens and ducks. Notably, novel reassortants and variants continually emerged and disseminated in avian populations, including H7N3, H9N9, H9N6 and H5N6 variants. Importantly, almost all of the H9 AIVs and many H7N9 and H6N2 strains prefer human-type receptors, posing an increased risk for human infections. In summary, our nation-wide surveillance highlights substantial changes in the circulation of AIVs since 2016, which greatly impacts the prevention and control of AIVs in China and worldwide.
Indexed as
Influenza A virusAnimalsBirdsChickensChinaDucksGenome, ViralHumansInfluenza A Virus, H7N3 SubtypeInfluenza A Virus, H7N9 SubtypeInfluenza A Virus, H9N2 SubtypeInfluenza, HumanInfluenza in BirdsPhylogenyPoultryReassortant Viruses
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