Observational studyScience immunology2020
Gut microbiota-specific IgA
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.
0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed
18.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 213 citations in OpenAlex.
- Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.Gut microbes · 2026Article
- Eggerthella lenta: metabolism, pathogenesis and therapeutic implications.Nature reviews. Microbiology · 2026Review
- Reframing the Gut-Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases.Annals of neurology · 2026Review
- The Gut-Brain Axis and Neurodegenerative Diseases: From Mechanistic Pathways to Therapeutic Interventions.Probiotics and antimicrobial proteins · 2026Review
- Using Synthetic Glycans to Investigate Anti-Glycan Antibodies and Explore Their Medical Potential.Angewandte Chemie (International ed. in English) · 2026Review
- IgA Deficiency Exacerbates an Animal Model of Multiple Sclerosis Induced with Theiler's Virus.Cells · 2026Article
- Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026Article
- Multiplex Detection of Immunoglobulins Uncovers Intrathecal IgA Elevation in Multiple Sclerosis.Cells · 2026Article
- Immunotherapy-Mediated Modulation of the Gut Microbiota in Multiple Sclerosis: The Effects of High-Efficacy (Cladribine) and Moderate-Efficacy (Interferon Beta-1a) Treatments.International journal of molecular sciences · 2026Article
- Systemic microbial antigen administration ameliorates experimental autoimmune encephalomyelitis via MHC-II downregulation in the CNS and secondary lymphoid organs.Journal of neuropathology and experimental neurology · 2026Article
- Human Blood IgAEuropean journal of immunology · 2026Article
- Female-enrichedbioRxiv : the preprint server for biology · 2026Article
- Chinese Herbal Medicine Targets Gut Microbiota to Combat Neurodegenerative Diseases: Potential Mechanisms and Clinical Implications.Journal of microbiology and biotechnology · 2026Review
- Spinal fluid antibody profile against bacteria demonstrates intrathecal antibody production in demyelinating diseases.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Microbial-Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies.European journal of immunology · 2026Review
- Function of the large intestine and its interaction with the brain after ischemic stroke: a comprehensive literature review.Frontiers in cellular neuroscience · 2026Review
- How gut microbiota contribute to neuropsychiatric disorders: evidence from neuroimaging studies.Frontiers in microbiology · 2026Review
- Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions.Brain, behavior, and immunity · 2026Article
- Gut microbiota and gut-derived metabolites in defining multiple sclerosis phenotypic continuum.Frontiers in immunology · 2026Review
- Total cerebrospinal fluid IgA as a candidate adjunctive biomarker associated with autoimmune encephalitis: a retrospective case-control study.Frontiers in neurology · 2026Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 8 institutions in 5 countries.
Anne-Katrin PröbstelDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. anne-katrin.proebstel@usb.ch sergio.baranzini@ucsf.edu.ORCID 0000-0002-7748-1872
Xiaoyuan ZhouDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-7410-3625
Ryan BaumannDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Sven WischnewskiDepartment of Neurology and Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0001-8714-1196
Michael KutzaDepartment of Neurology and Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0002-1471-8377
Olga L RojasDepartment of Immunology, University of Toronto, Toronto, ON M5S 18A, Canada.ORCID 0000-0003-2300-1658
Katrin SellrieDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14776 Potsdam, Germany.
Antje BischofDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-3862-5738
Kicheol KimDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-3667-9900
Akshaya RameshDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Ravi DandekarDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-2930-3043
Ariele L GreenfieldDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-4117-8986
Ryan D SchubertDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-3132-5831
Jordan E BisanzDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-8649-1706
Stephanie VistnesEli and Edythe Broad Center for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-7691-8633
Khashayar KhaleghiDepartment of Immunology, University of Toronto, Toronto, ON M5S 18A, Canada.
James LandefeldDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-6203-8667
Gina KirkishDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-0166-0612
Friederike Liesche-StarneckerDepartment of Neuropathology, School of Medicine, Institute of Pathology, Technical University Munich, 81675 Munich, Germany.
Valeria RamagliaDepartment of Neurology and Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0002-9401-5988
Sneha SinghDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-6524-890X
Edwina B TranDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Patrick BarbaDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-4352-7788
Kelsey ZornDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-1227-2137
Johanna OechteringNeurologic Clinic and Policlinic and Research Center for Clinical Neuroimmunology and Neuroscience Basel, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital of Basel, University of Basel, 4031 Basel, Switzerland.
Karin ForsbergDepartment of Clinical Science, Neurosciences, Umeå University, 90185 Umeå, Sweden.ORCID 0000-0003-2911-6026
Lawrence R ShiowEli and Edythe Broad Center for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Roland G HenryDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-8232-7562
Jennifer GravesDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Bruce A C CreeDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Stephen L HauserDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-4932-4001
Jens KuhleNeurologic Clinic and Policlinic and Research Center for Clinical Neuroimmunology and Neuroscience Basel, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital of Basel, University of Basel, 4031 Basel, Switzerland.
Jeffrey M GelfandDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-5121-3319
Peter M AndersenDepartment of Clinical Science, Neurosciences, Umeå University, 90185 Umeå, Sweden.
Jürgen SchlegelDepartment of Neuropathology, School of Medicine, Institute of Pathology, Technical University Munich, 81675 Munich, Germany.
Peter J TurnbaughDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-0888-2875
Peter H SeebergerDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14776 Potsdam, Germany.ORCID 0000-0003-3394-8466
Jennifer L GommermanDepartment of Immunology, University of Toronto, Toronto, ON M5S 18A, Canada.ORCID 0000-0003-4576-6168
Michael R WilsonDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-8705-5084
Lucas SchirmerDepartment of Neurology and Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0001-7142-4116
Sergio E BaranziniDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. anne-katrin.proebstel@usb.ch sergio.baranzini@ucsf.edu.ORCID 0000-0003-0067-194X
University of California, San Francisco · USUniversity of Mannheim · DEUniversity of Toronto · CAMax Planck Institute of Colloids and Interfaces · DETechnical University of Munich · DEUmeå University · SEUniversity Hospital of Basel · CHBroad Center · US
Funding
ZIDOVUDINE &LAMIVUDINE &NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFM01RR001271 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$22.7MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MThe Role of B cells in the Origin and Progression of Multiple SclerosisR35NS111644 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEPHEN L HAUSER · 2019 to 2026
$9.1MNCRR NIH HHS M01 RR001271NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NINDS NIH HHS R35 NS111644
Abstract
Changes in gut microbiota composition and a diverse role of B cells have recently been implicated in multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease. Immunoglobulin A (IgA) is a key regulator at the mucosal interface. However, whether gut microbiota shape IgA responses and what role IgA
Indexed as
AdultAgedAged, 80 and overBiomarkersBiopsyB-LymphocytesBrainCase-Control StudiesFemaleGastrointestinal MicrobiomeHumansImmunity, MucosalImmunoglobulin AIntestinal MucosaLongitudinal StudiesMagnetic Resonance ImagingBiomarkersImmunoglobulin A
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.