Evidence map›Paper›PMID 33219051›Full record

ArticleeNeuro

Sodium-Taste Cells Require

Makoto Ohmoto, Masafumi Jyotaki, J Kevin Foskett, Ichiro Matsumoto

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Developing and regenerating a sense of taste.Current topics in developmental biology · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Cellular Diversity and Regeneration in Taste Buds.Current opinion in physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Makoto OhmotoMonell Chemical Senses Center, Philadelphia, PA 19104.
Masafumi JyotakiMonell Chemical Senses Center, Philadelphia, PA 19104.
J Kevin FoskettDepartment of Physiology, University of Pennsylvania, Philadelphia, PA 19104.
Ichiro MatsumotoMonell Chemical Senses Center, Philadelphia, PA 19104 imatsumoto@monell.org.
Monell Chemical Senses Center · USUniversity of Pennsylvania · US

Funding

Molecular physiology of CALHM ion channelsR01DC018278 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2020 to 2024
$2.7M
Role of CALHM1 ion channel in taste transductionR01DC012538 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2013 to 2017
$1.7M
Molecular Genetics of Fat TasteR01DC017503 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MATSUMOTO, ICHIRO · 2019 to 2023
$1.6M
Roles of Ascl1 for generation and differentiation of taste cellsR01DC015491 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MATSUMOTO, ICHIRO · 2016 to 2020
$1.6M
NIDCD NIH HHS R01 DC012538NIDCD NIH HHS R01 DC015491NIDCD NIH HHS R01 DC017503NIDCD NIH HHS R01 DC018278
6 · The paper itself

Abstract

Taste buds are maintained via continuous turnover of taste bud cells derived from local epithelial stem cells. A transcription factor Skn-1a (also known as Pou2f3) is required for the generation of sweet, umami (savory), and bitter taste cells that commonly express TRPM5 and CALHM ion channels. Here, we demonstrate that sodium-taste cells distributed only in the anterior oral epithelia and involved in evoking salty taste also require

Indexed as

TasteTaste BudsAnimalsMiceMice, Inbred C57BLMice, KnockoutSodiumSodiumsaltySkn-1asodium tastetaste cell

Identifiers

PMID33219051
PMCPMC7729297
OpenAlexW3098586349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.