ArticleScience advances2020
Spinal motoneurons of the human newborn are highly synchronized during leg movements.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 73 citations in OpenAlex.
- Hybrid sEMG decomposition method integrating gradient convolution kernel compensation and correlation-constrained FastICA.Journal of neuroengineering and rehabilitation · 2026Article
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- Leveraging neural drive to assess hand motor function in individuals with chronic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Analysis of motor units with high-density surface electromyography: methodological considerations and physiological significance.European journal of applied physiology · 2026Review
- Characterization of motor unit activities during isometric elbow flexion with different speeds.Journal of neuroengineering and rehabilitation · 2025Article
- State-dependent neural representations of muscle synergies in the spinal cord revealed by optogenetic stimulation.The Journal of physiology · 2025Article
- Higher dominant muscle strength is mediated by motor unit discharge rates and proportion of common synaptic inputs.Scientific reports · 2025Article
- Effects of fatigue on motor unit characteristics in isometric elbow contractions across age groups.Frontiers in neuroscience · 2025Article
- Quantitative assessment of signal quality and usability of EEG and EMG recordings with PEDOT:PSS-coated microneedle electrodes.Frontiers in neuroscience · 2025Article
- Unaltered Responses of Distal Motor Neurons to Non-Targeted Thoracic Spinal Cord Stimulation in Chronic Pain Patients.Pain and therapy · 2024Article
- A direct spinal cord-computer interface enables the control of the paralysed hand in spinal cord injury.Brain : a journal of neurology · 2024Article
- Human Cervical Epidural Spinal Electrogram Topographically Maps Distinct Volitional Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Intrinsic motoneuron properties in typical human development.The Journal of physiology · 2024Article
- Program with last minute abstracts of the Padua Days on Muscle and Mobility Medicine, 27 February - 2 March, 2024 (2024Pdm3).European journal of translational myology · 2024Article
- Five Padua days on muscle and mobility medicine (2024Pdm3) 27 February - 2 March, 2024 at Hotel Petrarca, Thermae of Euganean Hills, Padua, and San Luca Hall, Prato della Valle, Padua, Italy.European journal of translational myology · 2023Article
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- The Forces Generated by Agonist Muscles during Isometric Contractions Arise from Motor Unit Synergies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A myoelectric digital twin for fast and realistic modelling in deep learning.Nature communications · 2023Article
- Complexity of modular neuromuscular control increases and variability decreases during human locomotor development.Communications biology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motoneurons of neonatal rodents show synchronous activity that modulates the development of the neuromuscular system. However, the characteristics of the activity of human neonatal motoneurons are largely unknown. Using a noninvasive neural interface, we identified the discharge timings of individual spinal motoneurons in human newborns. We found highly synchronized activities of motoneurons of the tibialis anterior muscle, which were associated with fast leg movements. Although neonates' motor units exhibited discharge rates similar to those of adults, their synchronization was significantly greater than in adults. Moreover, neonatal motor units showed coherent oscillations in the delta band, which is directly translated into force generation. These results suggest that motoneuron synchronization in human neonates might be an important mechanism for controlling fast limb movements, such as those of primitive reflexes. In addition to help revealing mechanisms of development, the proposed neural interface might monitor children at risk of developing motor disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.