Evidence map›Paper›PMID 33218334›Full record

ArticleBMC surgery2020

Outcomes of hemi- versus whole liver transplantation in patients from mainland china with high model for end-stage liver disease scores: a matched analysis.

LingXiang Kong, Tao Lv, Li Jiang, Jian Yang, Jiayin Yang

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

LingXiang KongDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Tao LvDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Li JiangDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Jian YangDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Jiayin YangDepartment of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. docjackyang@126.com.ORCID http://orcid.org/0000-0003-2695-7006
Sichuan University · CN

Funding

1.3.5 project for disiplines of excellence, West China Hospital, Sichuan University No. ZY2017308National Major Science and Technology Projects of China 2017ZX10203205-001-004National Major Science and Technology Projects of China No. 2017ZX10203205-005-002
6 · The paper itself

Abstract

backgroundAdult hemiliver transplantation (AHLT) is an important approach given the current shortage of donor livers. However, the suitability of AHLT versus adult whole liver transplantation (AWLT) for recipients with high Model for End-Stage Liver Disease (MELD) scores remains controversial.

methodsWe divided patients undergoing AHLT and AWLT into subgroups according to their MELD scores (≥ 30: AHLT, n = 35; AWLT, n = 88; and < 30: AHLT, n = 323; AWLT, n = 323). Patients were matched by demographic data and perioperative conditions according to propensity scores. A cut-off value of 30 for MELD scores was determined by comparing the overall survival data of 735 cases of nontumor liver transplantation.

resultsAmong patients with an MELD score ≥ 30 and < 30, AHLT was found to be associated with increased warm ischemia time, operative time, hospitalization time, and intraoperative blood loss compared with AWLT (P < 0.05). In the MELD ≥ 30 group, although the 5-year survival rate was significantly higher for AWLT than for AHLT (P = 0.037), there was no significant difference between AWLT and AHLT in the MELD < 30 group (P = 0.832); however, we did not observe a significant increase in specific complications following AHLT among patients with a high MELD score (≥ 30). Among these patients, the incidence of complications classified as Clavien-Dindo grade III or above was significantly higher in patients undergoing AHLT than in those undergoing AWLT (25.7% vs. 11.4%, P = 0.047). For the MELD < 30 group, there was no significant difference in the incidence of complications classified as Clavien-Dindo grade III or above for patients undergoing AHLT or AWLT.

conclusionIn patients with an MELD score < 30, AHLT can achieve rates of mortality and overall survival comparable to AWLT. In those with an MELD score ≥ 30, the prognosis and incidence of complications classified as Clavien-Dindo III or above are significantly worse for AHLT than for AWLT; therefore, we may need to be more cautious regarding the conclusion that patients with a high MELD score can safely undergo AHLT.

Indexed as

End Stage Liver DiseaseAdultChinaFemaleHumansLiver TransplantationMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexTissue DonorsTreatment OutcomeLiver transplantation (LT)Living donor liver transplantation (LDLT)Model for End-Stage Liver Disease Scores (MELD)Split liver transplantation (SLT)

Identifiers

PMID33218334
PMCPMC7677100
OpenAlexW3103884239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.