Evidence map›Paper›PMID 33218185›Full record

ArticleCancers2020

Genetic Variants of the NKG2C/HLA-E Receptor-Ligand Axis Are Determinants of Progression-Free Survival and Therapy Outcome in Aggressive B-Cell Lymphoma.

Bettina Wagner, Ulrich Dührsen, Andreas Hüttmann, Holger Nückel, Rafael Tomoya Michita, Hana Rohn, Sabine Schramm, Peter A Horn, Vera Rebmann

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Identification ofJournal of gastrointestinal oncology · 2024
    Article
  2. Review
  3. Article
  4. Inhibitory NKG2AFrontiers in immunology · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Bettina WagnerInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Ulrich DührsenDepartment of Hematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-4034-9472
Andreas HüttmannDepartment of Hematology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-2230-3873
Holger NückelMedical Practice for Hematology, Oncology, Hemostaseology and Palliative Care, 44787 Bochum, Germany.
Rafael Tomoya MichitaDepartment of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul (UFRGS), Bento Gonçalves Avenue 9500, Campus do Vale, Porto Alegre, RS CEP 91501970, Brazil.
Hana RohnDepartment of Infectious Diseases, West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Sabine SchrammInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Peter A HornInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Vera RebmannInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-4660-3870
University of Duisburg-Essen · DEUniversidade Federal do Rio Grande do Sul · BR

Funding

Deutsche Krebshilfe 107592Deutsche Krebshilfe 109816Deutsche Krebshilfe 110515
6 · The paper itself

Abstract

Aggressive B-cell lymphomas account for the majority of non-Hodgkin lymphomas (B-NHL). NK cells govern the responses to anti-CD20 monoclonal antibodies and have emerged as attractive targets for immunotherapy in subtypes of B-NHL. NKG2C and its cognate ligand HLA-E represent key molecules for fine-tuning of NK cell-mediated immune responses. Here, we investigated the impact of genetic variants of

Indexed as

aggressive lymphomaHLA-ENHLNKG2C

Identifiers

PMID33218185
PMCPMC7699209
OpenAlexW3104498326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.