Evidence map›Paper›PMID 33218011›Full record

ArticleInternational journal of molecular sciences2020

3D Bioprinting of Human Adipose-Derived Stem Cells and Their Tenogenic Differentiation in Clinical-Grade Medium.

Deborah Stanco, Monica Boffito, Alessia Bogni, Luca Puricelli, Josefa Barrero, Gianni Soldati, Gianluca Ciardelli

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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  3. Mechanobiological Strategies to Enhance Ovine (Animals : an open access journal from MDPI · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Deborah StancoDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.ORCID 0000-0001-6973-1555
Monica BoffitoDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.ORCID 0000-0001-7637-2001
Alessia BogniEuropean Commission, Joint Research Centre (JRC), Via E. Fermi, 2749, 21027 Ispra, Italy.
Luca PuricelliEuropean Commission, Joint Research Centre (JRC), Via E. Fermi, 2749, 21027 Ispra, Italy.
Josefa BarreroEuropean Commission, Joint Research Centre (JRC), Via E. Fermi, 2749, 21027 Ispra, Italy.
Gianni SoldatiSwiss Stem Cell Foundation, Via in Pasquée 32, 6925 Gentilino, Switzerland.ORCID 0000-0001-6309-9456
Gianluca CiardelliDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.ORCID 0000-0003-0199-1427
Joint Research Centre · ITPolitecnico di Torino · IT

Funding

Horizon 2020 Framework Programme direct action of JRC (2013/743/EU Council Decision of 3 December 2013 establishing the specific programme implementing Horizon 2020)
6 · The paper itself

Abstract

Defining the best combination of cells and biomaterials is a key challenge for the development of tendon tissue engineering (TE) strategies. Adipose-derived stem cells (ASCs) are ideal candidates for this purpose. In addition, controlled cell-based products adherent to good manufacturing practice (GMP) are required for their clinical scale-up. With this aim, in this study, ASC 3D bioprinting and GMP-compliant tenogenic differentiation were investigated. In detail, primary human ASCs were embedded within a nanofibrillar-cellulose/alginate bioink and 3D-bioprinted into multi-layered square-grid matrices. Bioink viscoelastic properties and scaffold ultrastructural morphology were analyzed by rheology and scanning electron microscopy (SEM). The optimal cell concentration for printing among 3, 6 and 9 × 10

Indexed as

BioprintingCulture MediaPrinting, Three-DimensionalAdipose TissueCell Culture TechniquesCell DifferentiationHumansStem CellsTenocytesCulture Media3D bioprintingadipose-derived stem cellsalginatecollagennanocellulosescleraxistendon tissue engineeringtenogenic differentiationxenogenic-free

Identifiers

PMID33218011
PMCPMC7698777
OpenAlexW3100713060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.