Evidence map›Paper›PMID 33217999›Full record

ArticleInternational journal of molecular sciences2020

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging.

Young Eun Choi, Min Ji Song, Mari Hara, Kyoko Imanaka-Yoshida, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.Annual review of biomedical engineering · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Research Progress in Skin Aging, Metabolism, and Related Products.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Young Eun ChoiDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.ORCID 0000-0003-3815-4833
Min Ji SongDepartment of Dermatology, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID 0000-0002-5252-4522
Mari HaraDepartment of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
Kyoko Imanaka-YoshidaDepartment of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.ORCID 0000-0002-8919-7342
Dong Hun LeeDepartment of Dermatology, Seoul National University College of Medicine, Seoul 03080, Korea.
Jin Ho ChungDepartment of Dermatology, Seoul National University College of Medicine, Seoul 03080, Korea.
Seung-Taek LeeDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.ORCID 0000-0001-7300-9784
Seoul National University · KRMie University · JPYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tenascin C (TNC) is an element of the extracellular matrix (ECM) of various tissues, including the skin, and is involved in modulating ECM integrity and cell physiology. Although skin aging is apparently associated with changes in the ECM, little is known about the role of TNC in skin aging. In this study, we found that the

Indexed as

Signal TransductionSkin AgingAnimalsExtracellular MatrixFemaleHumansMatrix Metalloproteinase 1Matrix Metalloproteinase 13MiceMice, HairlessRNA, MessengerSmad2 ProteinSmad3 ProteinTenascinTransforming Growth Factor beta1Matrix Metalloproteinase 1Matrix Metalloproteinase 13Mmp13 protein, mouseMMP1 protein, humanRNA, MessengerSmad2 ProteinSMAD2 protein, humanSmad2 protein, mouseSmad3 ProteinSMAD3 protein, humanSmad3 protein, mouseTenascinTGFB1 protein, humanTgfb1 protein, mouseTNC protein, humanTnc protein, mouseTransforming Growth Factor beta1agingcollagenextracellular matrixfibroblastskintenascin CTGF-β

Identifiers

PMID33217999
PMCPMC7698786
OpenAlexW3097172197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.