Evidence map›Paper›PMID 33217981›Full record

ReviewViruses2020

Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections.

Zamaneh Hajikhezri, Mahmoud Darweesh, Göran Akusjärvi, Tanel Punga

Abstract readReview
In one paragraph

Review in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Low expression of MKRN1 promotes leukemia cell proliferation.European journal of medical research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zamaneh HajikhezriDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
Mahmoud DarweeshDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
Göran AkusjärviDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
Tanel PungaDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.ORCID 0000-0002-0561-367X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control different steps of RNA metabolism. Since virus infections interfere with RNA metabolism, dynamic changes in the CCCH-type zinc finger proteins and virus replication are expected to happen. In the present review, we will discuss how three CCCH-type zinc finger proteins, ZC3H11A, MKRN1, and U2AF1, interfere with human adenovirus replication. We will summarize the functions of these three cellular proteins and focus on their potential pro- or anti-viral activities during a lytic human adenovirus infection.

Indexed as

Host Microbial InteractionsAdenoviridaeAdenovirus Infections, HumanHumansNerve Tissue ProteinsNuclear ProteinsRibonucleoproteinsRNA-Binding ProteinsSplicing Factor U2AFVirus ReplicationZinc FingersMakorin ring finger protein 1Nerve Tissue ProteinsNuclear ProteinsRibonucleoproteinsRNA-Binding ProteinsSplicing Factor U2AFU2AF1 protein, humanZC3H11A protein, humanCCCH-typehuman adenovirusMKRN1U2AF1ZC3H11Azinc finger protein

Identifiers

PMID33217981
PMCPMC7698620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.