Evidence map›Paper›PMID 33217969›Full record

ArticleProteomes2020

The Constitutive Proteome of Human Aqueous Humor and Race Specific Alterations.

Sai Karthik Kodeboyina, Tae Jin Lee, Lara Churchwell, Lane Ulrich, Kathryn Bollinger, David Bogorad, Amy Estes, Wenbo Zhi, Shruti Sharma, Ashok Sharma

Open access · goldAbstract read
In one paragraph

Article in Proteomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  5. Article
  6. AHP DB: a reference database of proteins in the human aqueous humor.Database : the journal of biological databases and curation · 2024
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sai Karthik KodeboyinaCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.
Tae Jin LeeCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.
Lara ChurchwellCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.
Lane UlrichDepartment of Ophthalmology, Augusta University, Augusta, GA 30912, USA.
Kathryn BollingerDepartment of Ophthalmology, Augusta University, Augusta, GA 30912, USA.
David BogoradDepartment of Ophthalmology, Augusta University, Augusta, GA 30912, USA.
Amy EstesDepartment of Ophthalmology, Augusta University, Augusta, GA 30912, USA.
Wenbo ZhiCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.
Shruti SharmaCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.
Ashok SharmaCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-9597-4374
Augusta University · US

Funding

Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Proteomic Biomarkers for Glaucomatous Optic NeuropathyR01EY029728 · NEI · AUGUSTA UNIVERSITY · PI SHARMA, ASHOK · 2019 to 2022
$1.5M
NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY029728
6 · The paper itself

Abstract

Aqueous humor (AH) is the fluid in the anterior and posterior chambers of the eye that contains proteins regulating ocular homeostasis. Analysis of aqueous humor proteome is challenging, mainly due to low sample volume and protein concentration. In this study, by utilizing state of the art technology, we performed Liquid-Chromatography Mass spectrometry (LC-MS/MS) analysis of 88 aqueous humor samples from subjects undergoing cataract surgery. A total of 2263 unique proteins were identified, which were sub-divided into four categories that were based on their detection in the number of samples: High (

Indexed as

aqueous humormass spectrometryproteomics

Identifiers

PMID33217969
PMCPMC7709111
OpenAlexW3104915874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.