Evidence map›Paper›PMID 33217917›Full record

ArticleInternational journal of environmental research and public health2020

Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study.

Lisiane Freitas Leal, Sonia Marzia Grandi, Vanessa Iribarrem Avena Miranda, Tatiane da Silva Dal Pizzol, Robert William Platt, Mariângela Freitas da Silveira, Andréa Dâmaso Bertoldi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lisiane Freitas LealDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC H3A 1A2, Canada.ORCID 0000-0002-4151-8960
Sonia Marzia GrandiDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC H3A 1A2, Canada.ORCID 0000-0002-8576-7854
Vanessa Iribarrem Avena MirandaPrograma de Pós-graduação em Saúde Coletiva-PPGSCol, Universidade do Extremo Sul Catarinense, Criciúma 88806-000, Brazil.ORCID 0000-0002-9156-5036
Tatiane da Silva Dal PizzolPrograma de Pós-Graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul 90610-000, Brazil.ORCID 0000-0002-7566-7745
Robert William PlattDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC H3A 1A2, Canada.
Mariângela Freitas da SilveiraPrograma de Pós-graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas 96020-220, Brazil.ORCID 0000-0002-2861-7139
Andréa Dâmaso BertoldiPrograma de Pós-graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas 96020-220, Brazil.ORCID 0000-0002-4680-3197
McGill University · CAUniversidade Federal de Pelotas · BRUniversidade do Extremo Sul Catarinense · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

Wellcome Trust 095582
6 · The paper itself

Abstract

Hypertensive disorders of pregnancy account for approximately 22% of all maternal deaths in Latin America and the Caribbean. Pharmacotherapies play an important role in preventing and reducing the occurrence of adverse outcomes. However, the patterns of medications used for treating women with hypertensive disorders of pregnancy (HDP) living in this country is unclear. A population-based birth cohort study including 4262 women was conducted to describe the pattern of use of cardiovascular agents and acetylsalicylic acid between women with and without HDP in the 2015 Pelotas (Brazil) Birth Cohort. The prevalence of maternal and perinatal outcomes in this population was also assessed. HDP were classified according to Ministry of Health recommendations. Medications were defined using the Anatomical Therapeutic Chemical Classification System and the substance name. In this cohort, 1336 (31.3%) of women had HDP. Gestational hypertension was present in 636 (47.6%) women, 409 (30.6%) had chronic hypertension, 191 (14.3%) pre-eclampsia, and 89 (6.7%) pre-eclampsia superimposed on chronic hypertension. Approximately 70% of women with HDP reported not using any cardiovascular medications. Methyldopa in monotherapy was the most frequent treatment (16%), regardless of the type of HDP. Omega-3 was the medication most frequently reported by women without HDP. Preterm delivery, caesarean section, low birth weight, and neonatal intensive care admissions were more prevalent in women with HDP. Patterns of use of methyldopa were in-line with the Brazilian guidelines as the first-line therapy for HDP. However, the large number of women with HDP not using medications to manage HDP requires further investigation.

Indexed as

Antihypertensive AgentsHypertension, Pregnancy-InducedPre-EclampsiaBrazilCesarean SectionCohort StudiesFatty Acids, Omega-3FemaleHumansInfant, NewbornMethyldopaPregnancyAntihypertensive AgentsFatty Acids, Omega-3Methyldopabirth cohortcardiovascular agentshypertensive disorders of pregnancypharmacoepidemiologypre-eclampsiapregnancy

Identifiers

PMID33217917
PMCPMC7698775
OpenAlexW3099538199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.