ArticlePhytochemistry2021
Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701.
Article in Phytochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Fusaric Acid Analogs and Dimers from Marine-DerivedJournal of natural products · 2026Article
- Structural and Biochemical Characterization ofACS bio & med chem Au · 2026Article
- Recent Updates on the Secondary Metabolites fromJournal of fungi (Basel, Switzerland) · 2024Review
- Polyketides, diketopiperazines and an isochromanone from the marine-derived fungal strain Fusarium graminearum FM1010 from Hawaii.Phytochemistry · 2022Article
- A validated high-throughput method for assaying rat lungworm (Parasitology · 2022Article
- Aspochalasin H1: A New Cyclic Aspochalasin from Hawaiian Plant-Associated Endophytic FungusMolecules (Basel, Switzerland) · 2021Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Alarming rate of resistance to the existing antibiotics exhibits the importance of developing new antibiotic molecules from relatively under explored sources as well as implementing alternative approaches like antibiotic adjuvants. Six previously undescribed fungal polyketides, kaneoheoic acids A-F (1-6) were isolated from a fungal strain Fusarium sp. FM701 which was collected from a muddy sample of Hawaiian beach. The structures of these six compounds were elucidated by spectroscopic interpretation, including HRESIMS and NMR, and electronic circular dichroism (ECD) analysis. All six compounds that were inactive when tested alone showed significant antibacterial activity against Staphylococcus aureus and Bacillus subtilis, in the range of 10-80 μg/mL when assayed in combination with either chloramphenicol (half of the MIC, 1 μg/mL), an FDA approved antibiotic or disulfiram (6 μg/mL), an established antibiotic adjuvant that augmented the activity of antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.