Evidence map›Paper›PMID 33217629›Full record

ReviewBiomaterials2021

Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity.

Rohan S J Ingrole, Erkan Azizoglu, Maria Dul, James C Birchall, Harvinder S Gill, Mark R Prausnitz

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 171 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Rohan S J IngroleDepartment of Chemical Engineering, Texas Tech University, Lubbock, TX, 79409, USA.
Erkan AzizogluSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA; Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Izmir, 35100, Turkey.
Maria DulSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, UK.
James C BirchallSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, UK.
Harvinder S GillDepartment of Chemical Engineering, Texas Tech University, Lubbock, TX, 79409, USA.
Mark R PrausnitzSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA. Electronic address: prausnitz@gatech.edu.
Cardiff University · GBGeorgia Institute of Technology · USTexas Tech University · US

Funding

Microneedles for treatment of peanut allergyR01AI135197 · NIAID · TEXAS TECH UNIVERSITY · PI GILL, HARVINDER SINGH · 2018 to 2022
$3.3M
Microneedles for allergy immunotherapyR01AI121322 · NIAID · TEXAS TECH UNIVERSITY · PI GILL, HARVINDER SINGH · 2016 to 2020
$1.8M
NIAID NIH HHS R01 AI121322NIAID NIH HHS R01 AI135197
6 · The paper itself

Abstract

The powerful and intriguing idea that drives the emerging technology of microneedles-shrinking the standard needle to a micron scale-has fostered an entire field of microneedle study and subsequent exponential growth in research and product development. Originally enabled by microfabrication tools derived from the microelectronic industry, microneedles are now produced through a number of methods in a variety of forms including solid, coated, dissolvable, and hollow microneedles. They are used to deliver a broad spectrum of molecules, including small molecules, biomolecules, and vaccines, as well as various forms of energy into the skin, eye, and other tissues. Microneedles are also being exploited for use in diagnostics, as well as additional medical, cosmetic, and other applications. This review elucidates the relative roles of different aspects of microneedle technology development, as shown through scientific papers, patents, clinical studies, and internet/social media activity. Considering >1000 papers, 750 patents, and almost 80 clinical trials, we analyze different attributes of microneedles such as usage of microneedles, types of microneedles, testing environment, types of patent claims, and phases of clinical trials, as well as which institutions and people in academia and industry from different locations and in different journals are publishing, patenting, and otherwise studying the potential of microneedles. We conclude that there is robust and growing activity in the field of microneedles; the technology is rapidly developing and being used for novel applications to benefit human health and well-being.

Indexed as

Drug Delivery SystemsNeedlesAdministration, CutaneousHumansInternetMicroinjectionsClinical trialDiagnostic deviceMicroneedlePatentSkin patchTransdermal drug delivery

Identifiers

PMID33217629
PMCPMC8042615
OpenAlexW3096237715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.