Evidence map›Paper›PMID 33217609›Full record

ArticleBrain stimulation

Selective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal.

Lindsea C Booth, Song T Yao, Alla Korsak, David G S Farmer, Sally G Hood, Daniel McCormick, Quinn Boesley, Angela A Connelly, Stuart J McDougall, Willian S Korim and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

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  10. Molecular cell types as functional units of the efferent vagus nerve.Seminars in cell & developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 4 countries.

Lindsea C BoothFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Song T YaoFlorey Department of Neuroscience and Mental Health, MDHS, University of Melbourne, Melbourne, Australia.
Alla KorsakCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
David G S FarmerFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia; Department of Physiology, The University of Melbourne, Melbourne, Australia.
Sally G HoodFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Daniel McCormickDepartment of Physiology and Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Quinn BoesleyDepartment of Physiology and Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Angela A ConnellyDepartment of Physiology, The University of Melbourne, Melbourne, Australia.
Stuart J McDougallFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Willian S KorimFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Sarah-Jane GuildDepartment of Physiology and Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Svetlana MastitskayaCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Phuong LeFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Anja G TeschemacherPhysiology, Neuroscience and Pharmacology, University of Bristol, Bristol, UK.
Sergey KasparovPhysiology, Neuroscience and Pharmacology, University of Bristol, Bristol, UK; Baltic Federal University, Kaliningrad, Russian Federation.
Gareth L AcklandTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Simon C MalpasDepartment of Physiology and Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Robin M McAllenFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
Andrew M AllenDepartment of Physiology, The University of Melbourne, Melbourne, Australia.
Clive N MayFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia. Electronic address: clive.may@florey.edu.au.
Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. Electronic address: a.gourine@ucl.ac.uk.
The University of Melbourne · AUUniversity of Auckland · NZUniversity College London · GBImmanuel Kant Baltic Federal University · RUQueen Mary University of London · GBUniversity of Bristol · GB

Funding

British Heart Foundation PG/18/8/33540British Heart Foundation RG/14/4/30736British Heart Foundation RG/19/5/34463Medical Research Council MR/R01213X/1
6 · The paper itself

Abstract

backgroundElectrical stimulation applied to individual organs, peripheral nerves, or specific brain regions has been used to treat a range of medical conditions. In cardiovascular disease, autonomic dysfunction contributes to the disease progression and electrical stimulation of the vagus nerve has been pursued as a treatment for the purpose of restoring the autonomic balance. However, this approach lacks selectivity in activating function- and organ-specific vagal fibers and, despite promising results of many preclinical studies, has so far failed to translate into a clinical treatment of cardiovascular disease.

objectiveHere we report a successful application of optogenetics for selective stimulation of vagal efferent activity in a large animal model (sheep). METHODS AND

resultsTwelve weeks after viral transduction of a subset of vagal motoneurons, strong axonal membrane expression of the excitatory light-sensitive ion channel ChIEF was achieved in the efferent projections innervating thoracic organs and reaching beyond the level of the diaphragm. Blue laser or LED light (>10 mW mm

conclusionsThese findings demonstrate that in species with a large, multi-fascicled vagus nerve, it is possible to stimulate a specific sub-population of efferent fibers using light at a site remote from the vector delivery, marking an important step towards eventual clinical use of optogenetic technology for autonomic neuromodulation.

Indexed as

OptogeneticsVagus Nerve StimulationAnimalsMammalsMotor NeuronsRatsSheepVagus NerveAutonomic nervous systemBrainstemNeuromodulationOptogeneticVagal preganglionic neuronsVagus nerve stimulation

Identifiers

PMID33217609
PMCPMC7836098
OpenAlexW3099785733

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.