Evidence map›Paper›PMID 33217544›Full record

ReviewClinical immunology (Orlando, Fla.)2021

Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes.

Koichi Yuki, Lifei Hou, Miho Shibamura-Fujiogi, Sophia Koutsogiannaki, Sulpicio G Soriano

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical immunology (Orlando, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. The immunomodulatory mechanism of dexmedetomidine.International immunopharmacology · 2021
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Koichi YukiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: koichi.yuki@childrens.harvard.edu.
Lifei HouDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lifei.hou@childrens.harvard.edu.
Miho Shibamura-FujiogiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: miho.fujiogi@childrens.harvard.edu.
Sophia KoutsogiannakiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sophia.koutsogiannki@childrens.harvard.edu.
Sulpicio G SorianoDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sulpicio.soriano@childrens.harvard.edu.

Funding

The impact of anesthetic selection on sepsis outcome and its mechanismR01GM118277 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2016 to 2020
$1.8M
Surgical site infections and the role of anesthesia and bacterial ion transportersR01GM127600 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2020 to 2022
$1.1M
Immunomodulatory mechanism of volatile anestheticsK08GM101345 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2012 to 2016
$950k
Neutrophil-mediated multiple organ dysfunction during sepsisR21HD099194 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI KOUTSOGIANNAKI, SOPHIA, YUKI, KOICHI · 2020 to 2021
$487k
NICHD NIH HHS R21 HD099194NIGMS NIH HHS K08 GM101345NIGMS NIH HHS R01 GM118277NIGMS NIH HHS R01 GM127600
6 · The paper itself

Abstract

A growing literature has shown that volatile anesthetics are promiscuous molecules targeting multiple molecules, some of which are critical for immunological functions. We focused on studies that delineated target molecules of volatile anesthetics on immune cells and summarized the effects of volatile anesthetics on immune functions. We also presented the perspectives of studying volatile anesthetics-mediated immunomodulation.

Indexed as

Anesthetics, InhalationDesfluraneHumansIsofluraneMacrophagesMonocytesNeutrophil InfiltrationNeutrophilsPhagocytosisSevofluraneAnesthetics, InhalationDesfluraneIsofluraneSevofluraneImmunomodulationSurgeryVolatile anesthetics

Identifiers

PMID33217544
PMCPMC7856197

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.