ArticleThe Journal of infection2021
Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department.
Registry-linked trialOpen access · bronzeAbstract readLetterComment
In one paragraph
Article in The Journal of infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04953312 (Calprotectin Involvement in Emergency Hematopoiesis Observed in Severe COVID-19), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Calprotectin Involvement in Emergency Hematopoiesis Observed in Severe COVID-19
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- S100 Protein and Interleukin Biomarkers Among COVID-19 Subjects With and Without Pneumonia: A Systematic Review and Meta-Analysis.British journal of biomedical science · 2025Pooled it
- Elevated level of circulating calprotectin correlates with severity and high mortality in patients with COVID-19.Immunity, inflammation and disease · 2024Pooled it
- Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review.Annals of clinical and translational neurology · 2022Pooled it
- Serum Calprotectin in Hospitalized Patients with COVID-19 in Relation to High-Dimensional Serum Proteomic Patterns.International journal of molecular sciences · 2026Observational
- Blood calprotectin as a biomarker for infection and sepsis - the prospective CASCADE trial.BMC infectious diseases · 2024Observational
- Validation of Serum Calprotectin Relative to Other Biomarkers of Infection in Febrile Infants Presenting to the Emergency Department.Antibiotics (Basel, Switzerland) · 2024Article
- Successful management of concurrent COVID-19 and Pneumocystis Jirovecii Pneumonia in kidney transplant recipients: a case series.BMC pulmonary medicine · 2023Article
- Elevated Level of Circulating but Not Urine S100A8/A9 Identifies Poor COVID-19 Outcomes.ACS infectious diseases · 2023Article
- Analysis of Calprotectin as an Early Marker of Infections Is Economically Advantageous in Intensive Care-Treated Patients.Biomedicines · 2023Article
- Article
- Calprotectin Levels and Neutrophil Count Are Prognostic Markers of Mortality in COVID-19 Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Role of cystatin C and calprotectin as potential early prognostic biomarkers in COVID-19 patients admitted to a dedicated COVID care facility.Journal of family medicine and primary care · 2022Article
- Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium.Nature reviews. Cardiology · 2022Review
- Dynamics of circulating calprotectin accurately predict the outcome of moderate COVID-19 patients.EBioMedicine · 2022Article
- Calprotectin and Imbalances between Acute-Phase Mediators Are Associated with Critical Illness in COVID-19.International journal of molecular sciences · 2022Article
- Serum calprotectin is not an independent predictor of severe COVID-19 in ambulatory adult patients.The Journal of infection · 2022Article
- S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes.Cytokine & growth factor reviews · 2022Review
- Serum calprotectin as a novel biomarker for severity of COVID-19 disease.Irish journal of medical science · 2022Article
- Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample types.Clinica chimica acta; international journal of clinical chemistry · 2022Article
- Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study).Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Observational
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Wolfgang BauerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Emergency Medicine, Campus Benjamin Franklin, Berlin, Germany. Electronic address: wolfgang.bauer@charite.de.
Eva Diehl-WieseneckerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Emergency Medicine, Campus Benjamin Franklin, Berlin, Germany.
Jannis UlkeCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany.
Noa GaltungCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Emergency Medicine, Campus Benjamin Franklin, Berlin, Germany.
Aleksandra HavelkaDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; Gentian Diagnostics AB, Stockholm, Sweden.
J Kolja HegelLabor Berlin - Charité Vivantes Services GmbH, Berlin, Germany.
Rudolf TauberCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany; Labor Berlin - Charité Vivantes GmbH, Berlin, Germany.
Rajan SomasundaramCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Emergency Medicine, Campus Benjamin Franklin, Berlin, Germany.
Kai KappertCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany; Labor Berlin - Charité Vivantes GmbH, Berlin, Germany.
Freie Universität Berlin · DEHumboldt-Universität zu Berlin · DECharité - Universitätsmedizin Berlin · DEKarolinska Institutet · SE
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
COVID-19SARS-CoV-2Emergency Service, HospitalHumansLaboratoriesLeukocyte L1 Antigen ComplexLeukocyte L1 Antigen Complex
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04953312ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.