ReviewThe Journal of allergy and clinical immunology2021
The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds.
Review in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02192866 (Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies), which is not on this map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies
Who cites it
35 citing papers in PubMed, 80 citations in OpenAlex.
- Butyrate-Dependent Conformational Switch Promotes Nuclear Translocation of the Mustard Allergen Sin a 1 in Human Gut Epithelial Cells.Journal of agricultural and food chemistry · 2026Article
- Article
- Pistachio Allergy: Integrating Molecular Diagnostics and Clinical Phenotypes.Diagnostics (Basel, Switzerland) · 2026Review
- IgE Anti-Beta Coronaviruses Serology in Napoleon Soldiers, France.Journal of medical virology · 2026Article
- AllergenAI: a deep learning model predicting allergenicity based on protein sequence.BMC bioinformatics · 2025Article
- Research Advancements in Peanut Proteins, Their Allergenic Potentials, and the Approaches to Mitigate Peanut Allergenicity.Nutrients · 2025Review
- Fine resolution of the N-terminal IgE-binding epitope of Ara h 2: Discovery of variants with enhanced IgE binding.The Journal of allergy and clinical immunology · 2025Article
- Purification of Prudu6 from Almond and Its Cross-Reactivity with Glym6 from Soybean.International journal of molecular sciences · 2025Article
- Structural determinants of peanut-induced anaphylaxis.The Journal of allergy and clinical immunology · 2025Article
- Basophil Activation Test for the Improved Diagnosis of Peanut and Tree Nut Allergy.Current allergy and asthma reports · 2025Review
- Cross-IgE sensitization correlates with cross-anaphylaxis among peanut and multiple tree nuts in a murine model.Frontiers in allergy · 2025Article
- Impact of recombinant expression inFrontiers in immunology · 2025Article
- Spices, herbs and allergic reactions in children: myth or reality - a narrative review with scoping elements.Frontiers in allergy · 2025Review
- Walnut Jug r 1 is Responsible for Primary Sensitization among Patients Suffering Walnut-Hazelnut 2S Albumin Cross-Reactivity.Journal of agricultural and food chemistry · 2024Article
- A review and outlook on expression of animal proteins in plants.Frontiers in plant science · 2024Review
- Peanut Allergy and Component-Resolved Diagnostics Possibilities-What Are the Benefits?Nutrients · 2023Review
- Alanine Scanning of the Unstructured Region of Ara h 2 and of a Related Mimotope Reveals Critical Amino Acids for IgE Binding.Molecular nutrition & food research · 2023Article
- The updated Structural Database of Allergenic Proteins (SDAP 2.0) provides 3D models for allergens and incorporated bioinformatics tools.The journal of allergy and clinical immunology. Global · 2023Article
- Reactivity to allergenic food contaminants: A study on products on the market.Clinical and translational allergy · 2023Article
- IgE cross-inhibition between Ara h 1 and Ara h 2 is explained by complex formation of both major peanut allergens.The Journal of allergy and clinical immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Allergies to peanuts, tree nuts, and sesame seeds are among the most important food-related causes of anaphylaxis. Important clinical questions include: Why is there a variable occurrence of coallergy among these foods and Is this immunologically mediated? The clinical and immunologic data summarized here suggest an immunologic basis for these coallergies that is based on similarities among the 2S albumins. Data from component resolved diagnostics have highlighted the relationship between IgE binding to these allergens and the presence of IgE-mediated food allergy. Furthermore, in vitro and in vivo experiments provide strong evidence that the 2S albumins are the most important allergens in peanuts for inducing an allergic effector response. Although the 2S albumins are diverse, they have a common disulfide-linked core with similar physicochemical properties that make them prime candidates to explain much of the observed coallergy among peanuts, tree nuts, and sesame seeds. The well-established frequency of cashew and pistachio nut coallergy (64%-100%) highlights how the structural similarities among their 2S albumins may account for observed clinical cross-reactivity. A complete understanding of the physicochemical properties of the 2S albumins in peanuts, tree nuts, and sesame seeds will enhance our ability to diagnose, treat, and ultimately prevent these allergies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.