ReviewBiophysical journal2020
Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres.
Review in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Restoration of structural organization in engineered cardiac microtissues is promoted by cardiomyocyte beating.Communications biology · 2026Article
- Cardiac myofibril networks induce shear stress.NPJ systems biology and applications · 2026Article
- Phase-targeting rapid cryofixation of the beating heart and histological analysis unveil contractile state-dependent sarcomere dynamics.Scientific reports · 2026Article
- Myotendinous junction: a microenvironment favorable for short-term adaptations to resistance training following gastrocnemius muscle atrophy.Frontiers in physiology · 2025Article
- Biventricular intraventricular mechanical and electrical dyssynchrony in pulmonary arterial hypertension.Heliyon · 2024Article
- How to estimate the sarcomere size based on oblique sections of skeletal muscle.Journal of anatomy · 2023Article
- Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes.Research square · 2023Article
- Article
- Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging.The Journal of general physiology · 2023Article
- Relationship between intraventricular mechanical dyssynchrony and left ventricular systolic and diastolic performance: An in vivo experimental study.Physiological reports · 2023Article
- Linking muscle architecture and functionPeerJ · 2023Article
- Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts.APL bioengineering · 2022Article
- Article
- Sarcomere length in the beating heart: Synchronicity is optional.The Journal of general physiology · 2022Article
- Contractile State Dependent Sarcomere Length Variability in Isolated Guinea-Pig Cardiomyocytes.Frontiers in physiology · 2022Article
- Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart.The Journal of general physiology · 2021Article
- Force Measurements From Myofibril to Filament.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The smallest contractile unit in striated muscles is the sarcomere. Although some of the classic features of contraction assume a uniform behavior of sarcomeres within myofibrils, the occurrence of sarcomere length nonuniformities has been well recognized for years, but it is yet not well understood. In the past years, there has been a great advance in experiments using isolated myofibrils and sarcomeres that has allowed scientists to directly evaluate sarcomere length nonuniformity. This review will focus on studies conducted with these preparations to develop the hypotheses that 1) force production in myofibrils is largely altered and regulated by intersarcomere dynamics and that 2) the mechanical work of one sarcomere in a myofibril is transmitted to other sarcomeres in series. We evaluated studies looking into myofibril activation, relaxation, and force changes produced during activation. We conclude that force production in myofibrils is largely regulated by intersarcomere dynamics, which arises from the cooperative work of the contractile and elastic elements within a myofibril.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.