ArticleNeuron2021
Subcircuits of Deep and Superficial CA1 Place Cells Support Efficient Spatial Coding across Heterogeneous Environments.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 106 citations in OpenAlex.
- A wireless modular platform for neuro-behavioral recording and closed-loop manipulation in small animals.Nature methods · 2026Article
- Article
- Article
- Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells.Nature neuroscience · 2026Article
- Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons.The Journal of physiology · 2026Article
- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- Article
- Article
- Hippocampal microcircuits constrain the generation of epileptiform activity.bioRxiv : the preprint server for biology · 2026Article
- Excitatory synapses onto axonic spines jump-start action potentials and route information flow.Nature neuroscience · 2026Article
- GATE: Adaptive learning with working memory by information gating in multi-lamellar hippocampal formation.PLoS computational biology · 2026Article
- Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Simultaneous path-integration recalibration in head direction and place cells.Current biology : CB · 2026Article
- Review
- Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits.iScience · 2026Article
- Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026Article
- Time, space, memory and brain-body rhythms.Nature reviews. Neuroscience · 2026Review
- Time or distance encoding by hippocampal neurons via heterogeneous ramping rates.Nature communications · 2025Article
- Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain.Neuron · 2025Article
- Laminar organization of pyramidal neuron cell types defines distinct CA1 hippocampal subregions.Nature communications · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The hippocampus is thought to guide navigation by forming a cognitive map of space. Different environments differ in geometry and the availability of cues that can be used for navigation. Although several spatial coding mechanisms are known to coexist in the hippocampus, how they are influenced by various environmental features is not well understood. To address this issue, we examined the spatial coding characteristics of hippocampal neurons in mice and rats navigating in different environments. We found that CA1 place cells located in the superficial sublayer were more active in cue-poor environments and preferentially used a firing rate code driven by intra-hippocampal inputs. In contrast, place cells located in the deep sublayer were more active in cue-rich environments and used a phase code driven by entorhinal inputs. Switching between these two spatial coding modes was supported by the interaction between excitatory gamma inputs and local inhibition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.