ArticleMolecular cell2021
Structural Basis for Virulence Activation of Francisella tularensis.
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Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- MtvS1 and MtvS2 Interact with RNA polymerase to regulate the Francisella type V-A CRISPR-Cas system.Nature communications · 2026Article
- Immunosensors and Immunoassays to DetectBiosensors · 2026Review
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- Dillapiole Dampens the Expression of the Major Virulence Genes ofMolecules (Basel, Switzerland) · 2025Article
- Bacterial alarmone (p)ppGpp mediates the pathogenicity ofmSystems · 2025Article
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- SspA is a transcriptional regulator of CRISPR adaptation in E. coli.Nucleic acids research · 2025Article
- Transcription activation inEcoSal Plus · 2024Review
- The DNA damage response ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evidence for a compact σiScience · 2024Article
- Breaking the cellular defense: the role of autophagy evasion inFrontiers in cellular and infection microbiology · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress.PLoS pathogens · 2023Article
- Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- The structural mechanism for transcription activation by Caulobacter crescentus GcrA.Nucleic acids research · 2023Article
- A Ribosomal Protein Homolog Governs Gene Expression and Virulence in a Bacterial Pathogen.Journal of bacteriology · 2022Article
- Structural and Functional Analysis of Toxin and Small RNA Gene Promoter Regions in Bacillus anthracis.Journal of bacteriology · 2022Article
- DnaA and SspA regulation of the iraD gene of Escherichia coli: an alternative DNA damage response independent of LexA/RecA.Genetics · 2022Article
- Diverse molecular mechanisms of transcription regulation by the bacterial alarmone ppGpp.Molecular microbiology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Brady A TravisDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Kathryn M RamseyDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cell and Molecular Biology and Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA.
Samantha M PreziosoDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Thomas TalloDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jamie M WandzilakDepartment of Cell and Molecular Biology and Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA.
Allen HsuGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Mario BorgniaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Alberto BartesaghiDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA; Department of Computer Science, Duke University, Durham, NC 27708, USA.
Simon L DoveDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: simon.dove@childrens.harvard.edu.
Richard G BrennanDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: richard.brennan@duke.edu.
Maria A SchumacherDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: maria.schumacher@duke.edu.
Duke University · USBoston Children's Hospital · USHarvard University · USNational Institute of Environmental Health Sciences · USNational Institutes of Health · USUniversity of Rhode Island · US
Funding
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8MUser Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MNIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0MDeciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular levelR35GM130290 · NIGMS · DUKE UNIVERSITY · PI Maria Schumacher · 2019 to 2026
$4.9MMolecular elucidation of the Francisella tularensis virulence mechanismR01AI154524 · NIAID · DUKE UNIVERSITY · PI BRENNAN, RICHARD GERALD, DOVE, SIMON L · 2021 to 2025
$4.0MIdentity, function and control of Francisella effectors encoded outside its pathogenicity islandR01AI145954 · NIAID · UNIVERSITY OF WASHINGTON · PI DOVE, SIMON L, MOUGOUS, JOSEPH DAVID · 2019 to 2023
$3.7MPediatric Infectious Diseases Research TrainingT32HD055148 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2008 to 2018
$2.7MEliminating Critical Systematic Errors In Structural Biology With Next-Generation SimulationR01GM124149 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLTON, JAMES M · 2017 to 2024
$2.5MControl of virulence gene expression in Francisella tularensisR01AI081693 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DOVE, SIMON L · 2010 to 2014
$2.1MControl of virulence gene expression in Francisella tularensisR56AI081693 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DOVE, SIMON L · 2018 to 2018
$489kStructural Elucidation of the Novel RNA Polymerase Underlying Francisella Tularensis VirulenceR21AI146641 · NIAID · DUKE UNIVERSITY · PI BRENNAN, RICHARD GERALD, SCHUMACHER, MARIA · 2020 to 2021
$429kStructural studies of virulence activation in Francisella tularensisF31AI150138 · NIAID · DUKE UNIVERSITY · PI TRAVIS, BRADY A · 2020 to 2021
$73kIntramural NIH HHS ZIC ES103326NIAID NIH HHS F31 AI150138NIAID NIH HHS R01 AI081693NIAID NIH HHS R01 AI145954NIAID NIH HHS R01 AI154524NIAID NIH HHS R21 AI146641NIAID NIH HHS R56 AI081693NICHD NIH HHS T32 HD055148NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM124149NIGMS NIH HHS R35 GM130290NIGMS NIH HHS U24 GM129547
Abstract
The bacterium Francisella tularensis (Ft) is one of the most infectious agents known. Ft virulence is controlled by a unique combination of transcription regulators: the MglA-SspA heterodimer, PigR, and the stress signal, ppGpp. MglA-SspA assembles with the σ
Indexed as
DNA-Directed RNA PolymerasesFrancisella tularensisPromoter Regions, GeneticSigma FactorVirulence FactorsEscherichia coliDNA-Directed RNA PolymerasesRNA polymerase sigma 70Sigma FactorVirulence FactorsCryo-EMFrancisella tularensisMglA-SspApathogenicity islandPigRppGppRNA polymerasetranscriptionαCTDσ70
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.