Evidence map›Paper›PMID 33217242›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells.

Tatiana Zyrianova, Benjamin Lopez, Andy Liao, Charles Gu, Leanne Wong, Michela Ottolia, Riccardo Olcese, Andreas Schwingshackl

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  4. Article
  5. Article
  6. Activation of TREK-1 (American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tatiana ZyrianovaDepartment of Pediatrics.
Benjamin LopezDepartment of Pediatrics.
Andy LiaoDepartment of Pediatrics.
Charles GuDepartment of Pediatrics.
Leanne WongDepartment of Pediatrics.
Michela OttoliaDepartment of Anesthesiology and Perioperative Medicine, and.
Riccardo OlceseDepartment of Anesthesiology and Perioperative Medicine, and.
Andreas SchwingshacklDepartment of Pediatrics.
University of California, Los Angeles · US

Funding

Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung InjuryR01HL146821 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHWINGSHACKL, ANDREAS · 2020 to 2024
$2.8M
The Role of TREK-1 potassium channels in ARDSR01HL175464 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Andreas Schwingshackl · 2024 to 2026
$2.3M
The Late L-type Ca Current as the Target for a New Class of AntiarrhythmicsR01HL134346 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2017 to 2020
$2.3M
The Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulationR01HL130308 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OTTOLIA, MICHELA · 2016 to 2019
$1.6M
The Role of 2-Pore Domain Potassium Channels in Acute Lung Injury.K08HL118118 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SCHWINGSHACKL, ANDREAS · 2014 to 2018
$792k
NHLBI NIH HHS K08 HL118118NHLBI NIH HHS R01 HL130308NHLBI NIH HHS R01 HL134346NHLBI NIH HHS R01 HL146821NHLBI NIH HHS R01 HL175464
6 · The paper itself

Abstract

We recently established a role for the stretch-activated two-pore-domain K

Indexed as

A549 CellsAcute Lung InjuryAlveolar Epithelial CellsCalciumCell LineCell Line, TumorChemokine CCL2CytokinesEndothelial CellsHEK293 CellsHumansHyperoxiaInflammationInterleukin-6Large-Conductance Calcium-Activated Potassium ChannelsLipopolysaccharidesCalciumCCL2 protein, humanChemokine CCL2CytokinesInterleukin-6Large-Conductance Calcium-Activated Potassium ChannelsLipopolysaccharidespotassium channel protein TREK-1Potassium Channels, Tandem Pore Domainacute lung injurycytokinesinflammationlarge conductance potassium channelsLPS

Identifiers

PMID33217242
PMCPMC7874395
OpenAlexW3104711943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.