ArticleThe clinical respiratory journal2021
Vitamin D deficiency is associated with chronic obstructive pulmonary disease and exacerbation of COPD.
Article in The clinical respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review.Nutrition reviews · 2022Pooled it
- Serum Vitamin D Levels, Systemic Inflammation, and Exacerbation Among Patients with COPD GOLD Group E.Biomedicines · 2026Article
- 25-Hydroxyvitamin D Deficiency Elevates the Risk of COPD Incidence and Mortality: A Large Population-Based Prospective Cohort Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Mendelian Randomization Study in East Asian Populations Supports the Causal Relationship Between Blood Metabolites and COPD: Insights from Amino Acids, Phospholipids, Vitamin D, and Trace Elements.International journal of chronic obstructive pulmonary disease · 2026Article
- Evaluation of micronutrients in stable COPD patients.Asia Pacific journal of clinical nutrition · 2025Article
- Article
- Medical nutrition therapy in chronic obstructive pulmonary disease: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Review
- Lower Vitamin D During Acute Exacerbation Is Associated with Very Severe Chronic Obstructive Pulmonary Disease.Medicina (Kaunas, Lithuania) · 2025Observational
- The Role of Severe Vitamin D Deficiency in Predicting the Risk of Severe Exacerbation in Patients With Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Observational
- Clinical value of Vitamin-D combined with budesonide/formoterol and theophylline sodium glycinate sustained-release tablets in the treatment of chronic obstructive pulmonary disease patients.Pakistan journal of medical sciences · 2024Article
- Association of dietary niacin intake with the prevalence and incidence of chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Vitamin D metabolism-related single nucleotide polymorphisms in Chronic Obstructive Pulmonary Disease risk.Frontiers in endocrinology · 2024Article
- Vitamin D supplementation may be beneficial in improving the prognosis of patients with chronic obstructive pulmonary disease in the intensive care unit: a retrospective study.Frontiers in medicine · 2024Article
- Unmasking the Silent Threat: Periodontal Health's Impact on COPD Severity and Hospitalization.Journal of personalized medicine · 2023Article
- The Effectiveness of Supplementation with Key Vitamins, Minerals, Antioxidants and Specific Nutritional Supplements in COPD-A Review.Nutrients · 2023Review
- Vitamin D status and chronic obstructive pulmonary disease risk: a prospective UK Biobank study.BMJ open respiratory research · 2023Article
- Analyses of Factors Associated with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2023Review
- The effect of prescribing vitamin D analogues and serum vitamin D status on both contracting COVID-19 and clinical outcomes in kidney dialysis patients'.Nephrology (Carlton, Vic.) · 2022Observational
- Calcifediol for Use in Treatment of Respiratory Disease.Nutrients · 2022Review
- The Effect of Teach-Back Combined with King Interactive Standard Mode on the Life of COPD Patients.Contrast media & molecular imaging · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionLow Vitamin D levels have been associated with Chronic Obstructive Pulmonary Disease (COPD) and acute exacerbations.
objectivesThere is a paucity of data on Vitamin D and COPD, its severity and exacerbations in populations that are exposed to sunlight regularly with high levels of physical activity most of their lives.
methodsSerum levels of 25-OH-Vitamin-D were assessed in 100 COPD subjects and 100 age- and gender-matched controls from the rural community-based MUDHRA cohort in South India. Levels of <20 ng/mL were defined as Vitamin D deficiency. Smoking habits, occupation, Charlson co-morbidity index, Standard of living index(SLI), body mass index(BMI), 6-minute walking distance were examined for associations with logistic regression between controls and COPD subjects. Unconditional logistic regression was used to examine the association with exacerbation of COPD.
resultsVitamin D deficiency was observed in 64.5% (95%CI 57.7-70.8) of the subjects in spite of regular exposure to sunlight. Subjects with COPD had higher risk of Vitamin D deficiency (Adjusted OR: 5.05; 95%CI 1.4-17.8) as compared to controls. Amongst subjects with COPD, Vitamin D deficient subjects were three times more likely to have exacerbations in the previous year (Adjusted OR:3.51; 95%CI 1.27-9.67) as compared to COPD subjects without Vitamin D deficiency. Levels of Vitamin D <20.81 ng/mL and <18.45 ng/mL had the highest levels of combined sensitivity and specificity for COPD and acute exacerbation of COPD (AECOPD) respectively.
conclusionIn a rural population exposed to sunlight many hours a day throughout their lives, low Vitamin D levels were associated with COPD and exacerbations of COPD.
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