Evidence map›Paper›PMID 33216981›Full record

ArticleBiopolymers2020

Experimental and theoretical rationalization for the base pairing abilities of inosine, guanosine, adenosine, and their corresponding 8-oxo-7,8-dihydropurine, and 8-bromopurine analogues within A-form duplexes of RNA.

Austin Skinner, Chou-Hsun Yang, Kazuki Hincks, Haobin Wang, Marino J E Resendiz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biopolymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Austin SkinnerDepartment of Chemistry, University of Colorado Denver, Denver, Colorado, USA.
Chou-Hsun YangDepartment of Chemistry, University of Colorado Denver, Denver, Colorado, USA.
Kazuki HincksDepartment of Chemistry, University of Colorado Denver, Denver, Colorado, USA.
Haobin WangDepartment of Chemistry, University of Colorado Denver, Denver, Colorado, USA.
Marino J E ResendizDepartment of Chemistry, University of Colorado Denver, Denver, Colorado, USA.
University of Colorado Denver · US

Funding

Characterizing Natural Product Mediated Microbial InteractionsR35GM128690 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PHELAN, VANESSA V · 2018 to 2022
$1.9M
Establishing the impact of 8-Oxo-7,8-dihydroguanosine (8-oxoG) on the structure and function of RNA. Part IIIR15GM132816 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Marino JE Resendiz, Haobin Wang · 2019 to 2026
$1.4M
Eureca grantL.S. Skaggs ProfessorshipNational Science Foundation ACI-1548562National Science Foundation CHE-1954639National Science Foundation NSF-MRI-1726947NIGMS NIH HHS 1R15GM132816NIGMS NIH HHS R15 GM132816NIGMS NIH HHS R35 GM128690NIH HHS R35GM128690Office of Science of the U.S. Department of Energy DE-AC02-05CH11231Research and Creative Activities AwardUniversity of Colorado Denver
6 · The paper itself

Abstract

Inosine is an important RNA modification, furthermore RNA oxidation has gained interest due, in part, to its potential role in the development/progression of disease as well as on its impact on RNA structure and function. In this report we established the base pairing abilities of purine nucleobases G, I, A, as well as their corresponding, 8-oxo-7,8-dihydropurine (common products of oxidation at the C8-position of purines), and 8-bromopurine (as probes to explore conformational changes), derivatives, namely 8-oxoG, 8-oxoI, 8-oxoA, 8-BrG, and 8-BrI. Dodecamers of RNA were obtained using standard phosphoramidite chemistry via solid-phase synthesis, and used as models to establish the impact that each of these nucleobases have on the thermal stability of duplexes, when base pairing to canonical and noncanonical nucleobases. Thermal stabilities were obtained from thermal denaturation transition (T

Indexed as

AdenosineBase PairingGuanineGuanosineHydrogen BondingInosineModels, ChemicalModels, GeneticMolecular StructureNucleic Acid ConformationRNAThermodynamics8-bromoguanine8-hydroxyguanineAdenosineGuanineGuanosineInosineRNA8-oxoA8-oxoG8-oxoIinosine within duplexes of RNARNA oxidationthermal stability of modified duplexes of RNA

Identifiers

PMID33216981
PMCPMC7780609
OpenAlexW3100224529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.