Evidence map›Paper›PMID 33216841›Full record

ArticleOncotarget2020

MEK is a promising target in the basal subtype of bladder cancer.

Nathan M Merrill, Nathalie M Vandecan, Kathleen C Day, Phillip L Palmbos, Mark L Day, Aaron M Udager, Sofia D Merajver, Matthew B Soellner

Abstract read
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Repurposing Amiodarone for Bladder Cancer Treatment.Cancer research communications · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nathan M MerrillDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Nathalie M VandecanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Kathleen C DayDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Phillip L PalmbosDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Mark L DayDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Aaron M UdagerUniversity of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
Sofia D MerajverDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Matthew B SoellnerDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Funding

Integrative signaling to increase efficacy of targeted therapies for triple negative breast cancerR21CA218498 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERAJVER, SOFIA DIANA, SOELLNER, MATTHEW B · 2017 to 2018
$373k
NCI NIH HHS R21 CA218498
6 · The paper itself

Abstract

While many resources exist for the drug screening of bladder cancer cell lines in 2D culture, it is widely recognized that screening in 3D culture is more representative of

Indexed as

3D culturebasal bladder cancerbladder cancerdrug screenMEK inhibition

Identifiers

PMID33216841
PMCPMC7646827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.