ArticleeLife2020
The amygdala instructs insular feedback for affective learning.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Chronic Alcohol Use and Accelerated Brain Aging: Shared Mechanisms with Alzheimer's Disease Pathophysiology.Brain sciences · 2025Review
- A Scoping Review of Neurotoxic and Behavioral Outcomes Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents.International journal of molecular sciences · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics.Nature communications · 2025Article
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.The journal of headache and pain · 2024Review
- Neurobiology of Pathogen Avoidance and Mate Choice: Current and Future Directions.Animals : an open access journal from MDPI · 2024Review
- Linking emotional valence and anxiety in a mouse insula-amygdala circuit.Nature communications · 2023Article
- Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding.Science advances · 2023Article
- Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation.Nature communications · 2023Article
- The Role of the Insular Cortex in Pain.International journal of molecular sciences · 2023Review
- Article
- Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways.Nature communications · 2022Article
- Encoding of Environmental Cues in Central Amygdala Neurons during Foraging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders.Frontiers in systems neuroscience · 2022Review
- Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics.Communications biology · 2021Article
- Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction.Science advances · 2021Review
- Dorsal Bed Nucleus of the Stria Terminalis-Subcortical Output Circuits Encode Positive Bias in Pavlovian Fear and Reward.Frontiers in neural circuits · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Affective responses depend on assigning value to environmental predictors of threat or reward. Neuroanatomically, this affective value is encoded at both cortical and subcortical levels. However, the purpose of this distributed representation across functional hierarchies remains unclear. Using fMRI in mice, we mapped a discrete cortico-limbic loop between insular cortex (IC), central amygdala (CE), and nucleus basalis of Meynert (NBM), which decomposes the affective value of a conditioned stimulus (CS) into its salience and valence components. In IC, learning integrated unconditioned stimulus (US)-evoked bodily states into CS valence. In turn, CS salience in the CE recruited these CS representations bottom-up via the cholinergic NBM. This way, the CE incorporated interoceptive feedback from IC to improve discrimination of CS valence. Consequently, opto-/chemogenetic uncoupling of hierarchical information flow disrupted affective learning and conditioned responding. Dysfunctional interactions in the IC↔CE/NBM network may underlie intolerance to uncertainty, observed in autism and related psychiatric conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.