Trial reportDiabetes technology & therapeutics2021
Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial.
Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Diabetes technology & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 5 pooled it
7.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Effect of Wearable Technology on Metabolic Control and the Quality of Life in Children and Adolescents with Type 1 Diabetes: A Systematic Review and Meta-AnalysisBalkan medical journal · 2024Pooled it
- International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guidelines 2024: Diabetes Technologies - Insulin Delivery.Hormone research in paediatrics · 2024Guideline
- Pooled it
- Automated Insulin Delivery Systems in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-analysis of Outpatient Randomized Controlled Trials.Diabetes care · 2023Pooled it
- Efficacy and safety of closed-loop control system for type one diabetes in adolescents a meta analysis.Scientific reports · 2023Pooled it
- Twelve-Month Follow-up from a Randomized Controlled Trial of Simplified Meal Announcement Versus Precise Carbohydrate Counting in Adolescents with Type 1 Diabetes Using the MiniMed™ 780G Advanced Hybrid Closed-Loop System.Diabetes technology & therapeutics · 2024Trial
- Patient reported outcomes (PROs) and user experiences of young children with type 1 diabetes using t:slim X2 insulin pump with control-IQ technology.Diabetes research and clinical practice · 2024Trial
- Updating Our Understanding of Device Use in Adolescents: Demographic Factors and Preferences in a Group of Adolescents With Type 1 Diabetes.The science of diabetes self-management and care · 2024Trial
- Trial
- Role of automated insulin delivery (AID) systems in glucose control in patients with diabetes mellitus undergoing dialysis in Calabria: AID-DIAL-CAL.Acta diabetologica · 2026Article
- [Diabetes mellitus and road traffic-A position paper of the Austrian Diabetes Association (Update 2026)].Wiener klinische Wochenschrift · 2026Article
- Improving glycaemic outcomes with subsidised access to diabetes technology in a young adult population with type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Real-world glycaemic outcomes observed with the use of Medtronic 780G, Tandem Control-IQ and Omnipod 5 automated insulin delivery systems.Diabetic medicine : a journal of the British Diabetic Association · 2026Observational
- Sensor-based digital health technologies to capture endpoints in recent clinical trials: a scoping review.NPJ digital medicine · 2026Article
- 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- Developing eHealth Interventions to Improve Diabetes Management in Emerging Adulthood: Qualitative Formative Study.JMIR formative research · 2025Article
- Article
- An Ethical Framework for Addressing the Differential Impact of Systemic Racism and Inequities on Type 1 and Type 2 Diabetes Mellitus in Youth in the United States.Hormone research in paediatrics · 2025Review
- Early Stages of Automated Insulin Delivery.Diabetes technology & therapeutics · 2025Review
- Metabolic Models, in Silico Trials, and Algorithms.Diabetes technology & therapeutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 2 countries.
Elvira IsganaitisResearch Division, Department of Pediatrics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Dan RaghinaruJaeb Center for Health Research, Tampa, Florida, USA.
Louise Ambler-OsbornResearch Division, Department of Pediatrics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Jordan E PinskerSansum Diabetes Research Institute, Santa Barbara, CA, USA.
Bruce A BuckinghamPediatric Endocrinology and Diabetes, Stanford Children's Health, Stanford, California, USA.
R Paul WadwaBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Laya EkhlaspourPediatric Endocrinology and Diabetes, Stanford Children's Health, Stanford, California, USA.
Yogish C KudvaDivision of Endocrinology, Diabetes, Metabolism, Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Carol J LevyDepartment of Medicine, Endocrinology, Diabetes and Bone Diseases, Mount Sinai Diabetes Center, New York, New York, USA.
Gregory P ForlenzaBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Roy W BeckJaeb Center for Health Research, Tampa, Florida, USA.
Craig KollmanJaeb Center for Health Research, Tampa, Florida, USA.
John W LumJaeb Center for Health Research, Tampa, Florida, USA.
Sue A BrownEndocrinology and Metabolism Division, Department of Medicine, Center for Diabetes Technology, University of Virginia, Charlottesville, Virginia, USA.
Lori M LaffelResearch Division, Department of Pediatrics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
iDCL Trial Research Group
Jaeb Center for Health Research · USJoslin Diabetes Center · USUniversity of Colorado Anschutz Medical Campus · USStanford Health Care · USDiabetes Australia · AUSansum Diabetes Research Institute · USUniversity of Virginia · USMayo Clinic · US
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MStable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MClinical Acceptance of the Artificial Pancreas: the International Diabetes Closed Loop (iDCL) TrialUC4DK108483 · NIDDK · UNIVERSITY OF VIRGINIA · PI ANDERSON, STACEY, DOYLE, FRANCIS J · 2016 to 2016
$12.7MData Coordinating Center for Artificial Pancreas StudiesU24DK123768 · NIDDK · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI BECK, ROY W. · 2019 to 2020
$1.3MModeling and modulating insulin delivery in automated insulin delivery systems to accommodate for meal compositionsK23DK121942 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EKHLASPOUR, LAYA · 2020 to 2024
$964kImpact of Metabolic Health in Type 2 Diabetes on Sperm Epigenetic Marks in Humans: A Novel Intergenerational Mechanism for Metabolic Disease Risk TransmissionR21HD091974 · NICHD · JOSLIN DIABETES CENTER · PI ISGANAITIS, ELVIRA MARIE, PATTI, MARY E · 2018 to 2019
$462kNICHD NIH HHS R21 HD091974NIDDK NIH HHS K23 DK121942NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P60 DK020541NIDDK NIH HHS U24 DK123768NIDDK NIH HHS UC4 DK108483
Abstract
PubMed holds no abstract for this paper.
Indexed as
Blood GlucoseDiabetes Mellitus, Type 1AdolescentAdultGlycemic ControlHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsYoung AdultBlood GlucoseHypoglycemic AgentsInsulinAdolescentsClosed-loop control insulin deliveryTime in rangeYoung adult
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.