Evidence map›Paper›PMID 33216645›Full record

ArticleJCO global oncology2020

Improving Pediatric Neuro-Oncology Survival Disparities in the United States-Mexico Border Region: A Cross-Border Initiative Between San Diego, California, and Tijuana, Mexico.

Paula Aristizabal, Luke P Burns, Nikhil V Kumar, Bianca P Perdomo, Rebeca Rivera-Gomez, Mario A Ornelas, David Gonda, Denise Malicki, Courtney D Thornburg, William Roberts and 2 more

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Subtotal tumor resection as a predictor of post-resection hydrocephalus in pediatric patients with posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  3. Article
  4. Article
  5. Building a transdisciplinary network to improve survival in children with cancer in Colombia: seeds to forests.Revista panamericana de salud publica = Pan American journal of public health · 2025
    Article
  6. Article
  7. Unlocking delays: revealing barriers to early diagnosis of childhood central nervous system tumors in an upper-middle-income country.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Disparities in Pediatric Oncology: The 21st Century Opportunity to Improve Outcomes for Children and Adolescents With Cancer.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Paula AristizabalPeckham Center for Cancer and Blood Disorders, Rady Children's Hospital San Diego, San Diego, CA.ORCID 0000-0003-0588-1532
Luke P BurnsSchool of Medicine, University of California, San Diego, La Jolla, CA.
Nikhil V KumarSchool of Medicine, University of California, San Diego, La Jolla, CA.
Bianca P PerdomoDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Diego, La Jolla, CA.ORCID 0000-0003-2655-7926
Rebeca Rivera-GomezHospital General de Tijuana/Universidad Autónoma de Baja California Tijuana, Baja California, Mexico.
Mario A OrnelasHospital General de Tijuana/Universidad Autónoma de Baja California Tijuana, Baja California, Mexico.
David GondaDepartment of Neurosciences, University of California, San Diego, La Jolla, CA.
Denise MalickiDepartment of Pathology, University of California, San Diego, La Jolla, CA.
Courtney D ThornburgPeckham Center for Cancer and Blood Disorders, Rady Children's Hospital San Diego, San Diego, CA.
William RobertsPeckham Center for Cancer and Blood Disorders, Rady Children's Hospital San Diego, San Diego, CA.ORCID 0000-0002-2308-402X
Michael L LevyDepartment of Neurosciences, University of California, San Diego, La Jolla, CA.
John R CrawfordPeckham Center for Cancer and Blood Disorders, Rady Children's Hospital San Diego, San Diego, CA.
University of California San Diego · USUniversidad Autónoma de Baja California · MX

Funding

COMPRENDO: Adaptation and Implementation of a Peer-Navigation Intervention to Improve Research Literacy and Diversity in Pediatric Leukemia Clinical TrialsK08CA230306 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARISTIZABAL, PAULA · 2018 to 2023
$1.4M
NCI NIH HHS K08 CA230306
6 · The paper itself

Abstract

purposeTreatment of children with CNS tumors (CNSTs) demands a complex, interdisciplinary approach that is rarely available in low- and middle-income countries. We established the Cross-Border Neuro-Oncology Program (CBNP) between Rady Children's Hospital, San Diego (RCHSD), and Hospital General, Tijuana (HGT), Mexico, to provide access to neuro-oncology care, including neurosurgic services, for children with CNSTs diagnosed at HGT. Our purpose was to assess the feasibility of the CBNP across the United States-Mexico border and improve survival for children with CNSTs at HGT by implementing the CBNP. PATIENTS AND

methodsWe prospectively assessed clinicopathologic profiles, the extent of resection, progression-free survival, and overall survival (OS) in children with CNSTs at HGT from 2010 to 2017.

resultsSixty patients with CNSTs participated in the CBNP during the study period. The most common diagnoses were low-grade glioma (24.5%) and medulloblastoma (22.4%). Of patients who were eligible for surgery, 49 underwent resection at RCHSD and returned to HGT for collaborative management. Gross total resection was achieved in 78% of cases at RCHSD compared with 0% at HGT (

conclusionThe CBNP facilitated access to complex neuro-oncology care for underserved children in Mexico through binational exchanges of resources and expertise. Survival for patients in the CBNP dramatically improved. Gross total resection at RCHSD was associated with higher OS, highlighting the critical role of experienced neurosurgeons in the treatment of CNSTs. The CBNP model offers an attractive alternative for children with CNSTs in low- and middle-income countries who require complex neuro-oncology care, particularly those in close proximity to institutions in high-income countries with extensive neuro-oncology expertise.

Indexed as

Health Status DisparitiesCaliforniaChildEmigrants and ImmigrantsHumansMexico

Identifiers

PMID33216645
PMCPMC7713516
OpenAlexW3100979102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.