Observational studyCancer medicine2021
Metabolic health is a determining factor for incident colorectal cancer in the obese population: A nationwide population-based cohort study.
Observational study in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Association of metabolic obesity phenotypes with risk of overall and site-specific cancers: a systematic review and meta-analysis of cohort studies.British journal of cancer · 2024Pooled it
- Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies.BMC cancer · 2022Pooled it
- The Association Between Metabolic Status and Risk of Cancer Among Patients With Obesity: Metabolically Healthy Obesity vs. Metabolically Unhealthy Obesity.Frontiers in nutrition · 2022Pooled it
- Metabolic Syndrome Components and Cancer Risk in Normal-Weight Subjects: Systematic Review and Meta-Analysis in over 18 Million Individuals.Journal of clinical medicine · 2026Review
- Metabolic Phenotype and Risk of Obesity-Related Cancers in the Women's Health Initiative.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- Metabolic obesity phenotypes and obesity-related cancer risk in the National Health and Nutrition Examination Survey.Endocrinology, diabetes & metabolism · 2023Article
- Metabolic phenotypes and risk of end-stage kidney disease in patients with type 2 diabetes.Frontiers in endocrinology · 2023Article
- The Association Between Metabolic Syndrome and Colorectal Cancer Risk by Obesity Status in Korean Women: A Nationwide Cohort Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2022Article
- Pathogenesis, Murine Models, and Clinical Implications of Metabolically Healthy Obesity.International journal of molecular sciences · 2022Review
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- Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study.Frontiers in endocrinology · 2022Article
- Association between cardiovascular risk factors and colorectal cancer: A systematic review and meta-analysis of prospective cohort studies.EClinicalMedicine · 2021Article
- The Adipokine Component in the Molecular Regulation of Cancer Cell Survival, Proliferation and Metastasis.Pathology oncology research : POR · 2021Review
- HDL-C and Cardiovascular Risk: You Don't Need to Worry about Extremely High HDL-C Levels.Journal of lipid and atherosclerosis · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association of the risk of colorectal cancer (CRC) with obesity or obesity-induced metabolic disturbances remains controversial. We assessed the association of metabolic health status with incident CRC among subjects with obesity.
methodsThis study included 319,397 subjects from the Korean National Health Insurance Service-National Health Screening Cohort. Transitions in metabolic health status and obesity were examined during 2009-2010 and 2011-2012. We categorized subjects with obesity into four separate groups according to their dynamic metabolic health status: metabolically healthy obesity (MHO), MHO to metabolically unhealthy obesity (MUO), MUO to MHO, and stable MUO. Subjects were followed up from 2009 to 2015 for incident CRC.
resultsThe stable MHO group showed no increased risk of incident CRC (hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.83-1.14). However, the MHO to MUO group had a higher risk of incident CRC than the stable metabolically healthy nonobese (MHNO) group (HR, 1.34; 95% CI, 1.15-1.57). Among patients with MUO at baseline, those in the subgroup who transitioned to MHO group were not at increased risk of CRC (HR, 1.06; 95% CI, 0.91-1.25), whereas those who remained in the stable MUO group had a higher risk of incident CRC than those in the stable MHNO group (HR, 1.29; 95% CI, 1.19-1.41).
conclusionsThe transition of metabolic health was a determining factor for CRC among subjects with obesity. Hence, maintenance or recovery of metabolic health should be addressed to prevent CRC in individuals with obesity.
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