Evidence map›Paper›PMID 33216462›Full record

ArticleAnnals of clinical and translational neurology2020

Cardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies.

Guillaume Lamotte, Courtney Holmes, Patricia Sullivan, Abhishek Lenka, David S Goldstein

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Cardiovascular autonomic failure correlates with cutaneous autonomic denervation in PD and MSA.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Multitracer PET to Assess Cardiac Sympathetic Innervation and Vesicular Storage in Lewy Body Diseases.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Review
  5. 3,4-Dihydroxyphenylglycol levels separate multiple system atrophy from Parkinson disease with orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Observational
  6. Review
  7. Decreased urinary excretion of norepinephrine and dopamine in autonomic synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. IsClinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
  14. Observational
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guillaume LamotteClinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0003-4048-6095
Courtney HolmesAutonomic Medicine Section, CNP/DIR/NINDS/NIH, Bethesda, Maryland, USA.
Patricia SullivanAutonomic Medicine Section, CNP/DIR/NINDS/NIH, Bethesda, Maryland, USA.
Abhishek LenkaDepartment of Neurology, Medstar Georgetown University Hospital, Washington, District of Columbia, USA.
David S GoldsteinAutonomic Medicine Section, CNP/DIR/NINDS/NIH, Bethesda, Maryland, USA.ORCID 0000-0002-5709-9940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLewy body (LB) synucleinopathies such as Parkinson's disease (PD) entail profound cardiac norepinephrine deficiency. The status of sympathetic noradrenergic innervation at other extracranial sites has been unclear. Although in vivo neuroimaging studies have indicated a cardioselective noradrenergic lesion, no previous study has surveyed peripheral organs for norepinephrine contents in LB diseases. We reviewed

methods

resultsInterventricular septal

interpretationBy in vivo sympathetic neuroimaging and postmortem neurochemistry peripheral noradrenergic deficiency in LB synucleinopathies is cardioselective. MSA does not involve peripheral noradrenergic deficiency.

Indexed as

AgedAutopsyDopamineFemaleFluorine RadioisotopesHeartHeart SeptumHeart VentriclesHumansLewy Body DiseaseMaleMiddle AgedMultiple System AtrophyMyocardiumNorepinephrineParkinson DiseaseDopamineFluorine RadioisotopesNorepinephrine

Identifiers

PMID33216462
PMCPMC7732242

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.