ArticleJournal of diabetes2021
Does inpatient hyperglycemia predict a worse outcome in COVID-19 intensive care unit patients?
Article in Journal of diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Dietary glycemic index, glycemic load, and risk of COVID-19: a prospective cohort study.Journal of health, population, and nutrition · 2025Article
- Importance of Blood Glucose Measurement for Predicting the Prognosis of Long COVID: A Retrospective Study in Japan.Journal of clinical medicine · 2024Article
- Multi-Organ Systems Involvement in COVID-19 is Associated With a Worse Prognosis.Journal of acute medicine · 2024Article
- Endothelial dysfunction in autoimmune, pulmonary, and kidney systems, and exercise tolerance following SARS-CoV-2 infection.Frontiers in medicine · 2023Review
- Dexamethasone-induced hyperglycaemia in COVID-19: Glycaemic profile in patients without diabetes and factors associated with hyperglycaemia.Diabetes research and clinical practice · 2022Article
- Does the Hyperglycemia Impact on COVID-19 Outcomes Depend upon the Presence of Diabetes?-An Observational Study.Metabolites · 2022Article
- J-shaped associations and joint effects of fasting glucose with inflammation and cytokines on COVID-19 mortality.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Honghua extract mediated potent inhibition of COVID-19 host cell pathways.Scientific reports · 2022Article
- Article
- Inpatient glycemic control and community-acquired pneumonia outcomes in the pre-COVID-19 era: reviewing the evidence to pave the road for future studies.BMJ open diabetes research & care · 2022Article
- Impact of newly diagnosed diabetes on coronavirus disease 2019 severity and hyperglycemia.Journal of diabetes investigation · 2022Article
- Moderately hyperglycemia as an independent prognostic factor for the worse outcome of COVID-19.Primary care diabetes · 2022Article
- Sustained Hyperglycemia and Its Relationship with the Outcome of Hospitalized Patients with Severe COVID-19: Potential Role ofJournal of personalized medicine · 2022Article
- Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Review
- COVID-19 and the Endocrine System: A Review of the Current Information and Misinformation.Infectious disease reports · 2022Review
- Review
- Glucose dysregulation and its association with COVID-19 mortality and hospital length of stay.Diabetes & metabolic syndrome · 2022Article
- Diabetes, Metformin and the Clinical Course of Covid-19: Outcomes, Mechanisms and Suggestions on the Therapeutic Use of Metformin.Frontiers in pharmacology · 2022Review
- Hospital Length of Stay and Related Factors for COVID-19 Inpatients Among the Four Southern Regions Under the Proposed Southern Business Unit of Saudi Arabia.Journal of multidisciplinary healthcare · 2022Article
- The Role of Diabetes and Hyperglycemia on COVID-19 Infection Course-A Narrative Review.Frontiers in clinical diabetes and healthcare · 2022Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe undertook this study to evaluate the association between hyperglycemia and outcomes in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU).
methodsWe conducted a multicenter retrospective study involving all adults with COVID-19 admitted to the ICU between March and May 2020. Patients were divided into normoglycemic (average blood glucose <140 mg/dL) and hyperglycemic (average blood glucose ≥140 mg/dL) groups. Outcomes such as mortality, need and duration of mechanical ventilation, and length of hospital and ICU stays were measured.
resultsAmong 495 patients, 58.4% were male with a median age of 68 years (interquartile range [IQR]: 58.00-77.00), and baseline average blood glucose was 186.6 (SD ± 130.8). Preexisting diabetes was present in 35.8% of the studied cohort. Combined ICU and hospital mortality rates were 23.8%; mortality and mechanical ventilation rates were significantly higher in the hyperglycemic group with 31.4% vs 16.6% (P = .001) and 50.0% vs 37.2% (P = .004), respectively. Age above 60 years (hazard ratio [HR] 3.21; 95% CI 1.78, 5.78) and hyperglycemia (HR 1.79; 95% CI 1.14, 2.82) were the only significant predictors of in-hospital mortality. Increased risk for hyperglycemia was found in patients with steroid use (odds ratio [OR] 1.521; 95% CI 1.054, 2.194), triglycerides ≥150 mg/dL (OR 1.62; 95% CI 1.109, 2.379), and African American race (OR 0.79; 95% CI 0.65, 0.95).
conclusionsHyperglycemia in patients with COVID-19 is significantly associated with a prolonged ICU length of stay, higher need of mechanical ventilation, and increased risk of mortality in the critical care setting. Tighter blood glucose control (≤140 mg/dL) might improve outcomes in COVID-19 critically ill patients; evidence from ongoing clinical trials is needed.
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