ArticleMagnetic resonance in medicine2021
Repeatability and reliability of GABA measurements with magnetic resonance spectroscopy in healthy young adults.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- In Vivo Glx Measurements From GABA-Edited HERMES at 3 T Are Not Consistent With Those From Short-TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups.NMR in biomedicine · 2026Article
- The consequences of using statistical tests on proxy measurements in place of gold standard measurements: an application to magnetic resonance spectroscopy.Scientific reports · 2025Article
- Test-retest reliability and repeatability of behavioral and electrophysiological markers of cognitive control in an Eriksen Flanker Task.Cognitive, affective & behavioral neuroscience · 2025Article
- State-dependent reactivity of anterior cingulate cortex neurochemistry and downstream autonomic arousal in intrusive thinking.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Test-retest precision of brain metabolites in healthy participants usingQuantitative imaging in medicine and surgery · 2025Article
- Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects.The American journal of psychiatry · 2024Article
- Effects of GABA, Sex, and Stress on Reward Learning in Current and Remitted Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Impact of acquisition and modeling parameters on the test-retest reproducibility of edited GABA.NMR in biomedicine · 2024Article
- The intra-individual reliability ofHuman brain mapping · 2024Article
- Neural response to stress differs by sex in young adulthood.Psychiatry research. Neuroimaging · 2023Article
- Evaluating Back-to-Back and Day-to-Day Reproducibility of Cortical GABA+ Measurements Using Proton Magnetic Resonance Spectroscopy (International journal of molecular sciences · 2023Article
- Quantifying GABA in Addiction: A Review of Proton Magnetic Resonance Spectroscopy Studies.Brain sciences · 2022Review
- Comparison of seven modelling algorithms for γ-aminobutyric acid-edited proton magnetic resonance spectroscopy.NMR in biomedicine · 2022Article
- Regional specificity and clinical correlates of cortical GABA alterations in posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- MR Spectroscopy of the Insula: Within- and between-Session Reproducibility of MEGA-PRESS Measurements of GABA+ and Other Metabolites.Brain sciences · 2021Article
- Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
purposeGamma-aminobutyric acid (GABA) abnormalities have been implicated in a range of neuropsychiatric disorders. Despite substantial interest in probing GABA in vivo, human imaging studies relying on magnetic resonance spectroscopy (MRS) have generally been hindered by technical challenges, including GABA's relatively low concentration and spectral overlap with other metabolites. Although past studies have shown moderate-to-strong test-retest repeatability and reliability of GABA within certain brain regions, many of these studies have been limited by small sample sizes.
methodsGABA+ (macromolecular-contaminated) test-retest reliability and repeatability were assessed via a Meshcher-Garwood point resolved spectroscopy (MEGA-PRESS) MRS sequence in the rostral anterior cingulate cortex (rACC; n = 21) and dorsolateral prefrontal cortex (dlPFC; n = 20) in healthy young adults. Data were collected on a 3T scanner (Siemens Prisma, Siemens Healthcare, Erlangen, Germany) and GABA+ results were reported in reference to both total creatine (GABA+/tCr) and water (GABA+/water).
resultsResults showed strong test-retest repeatability (mean GABA+/tCr coefficient of variation [CV] = 4.6%; mean GABA+/water CV = 4.0%) and reliability (GABA+/tCr intraclass correlation coefficient [ICC] = 0.77; GABA+/water ICC = 0.87) in the dlPFC. The rACC showed acceptable (but comparatively lower) repeatability (mean GABA+/tCr CV = 8.0%; mean GABA+/water CV = 7.5%), yet low-moderate reliability (GABA+/tCr ICC = 0.40; GABA+/water ICC = 0.44).
conclusionThe present study found excellent GABA+ MRS repeatability and reliability in the dlPFC. The rACC showed inferior results, possibly because of a combination of shimming impedance and measurement error. These data suggest that MEGA-PRESS can be utilized to reliably distinguish participants based on dlPFC GABA+ levels, whereas the mixed results in the rACC merit further investigation.
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