Evidence map›Paper›PMID 33216305›Full record

ArticleEndocrine2021

Peripherally restricted cannabinoid type 1 receptor (CB1R) antagonist, AM6545, potentiates stress-induced hypothalamic-pituitary-adrenal axis activation via a non-CB1R mechanism.

Christopher J Roberts, Cecilia J Hillard

Open access · greenAbstract readLetter
In one paragraph

Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher J RobertsDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. croberts@mcw.edu.ORCID 0000-0003-0889-8567
Cecilia J HillardDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Medical College of Wisconsin · US

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Circuit-specific actions of endocannabinoids in stress and mood disordersR01MH121454 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J, LIU, QING-SONG · 2019 to 2023
$1.9M
Cannabinoid regulation of glycogen synthase kinase-3R01DA026996 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J · 2010 to 2014
$1.7M
Anesthesiology Research Training ProgramT32GM089586 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI EBERT, THOMAS JAY · 2010 to 2019
$1.5M
Examining the impact of circulating endocannabinoid levels on neurocognition, mood, and early cannabis use in youth enrolled in the ABCD StudyR21DA049109 · NIDA · UNIVERSITY OF WISCONSIN MILWAUKEE · PI HILLARD, CECILIA J, LISDAHL, KRISTA MAURINE · 2019 to 2020
$433k
Gender differences in the interactions between endocannabinoids and stressR21DA022439 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J · 2007 to 2008
$421k
NIDA NIH HHS R01 DA026996NIDA NIH HHS R21 DA022439NIDA NIH HHS R21 DA049109NIGMS NIH HHS T32 GM080202NIGMS NIH HHS T32 GM089586NIMH NIH HHS R01 MH121454
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hypothalamo-Hypophyseal SystemPituitary-Adrenal SystemAnimalsCannabinoid Receptor AntagonistsFemaleMaleMiceMice, Inbred ICRMorpholinesPyrazolesReceptor, Cannabinoid, CB1AM6545Cannabinoid Receptor AntagonistsMorpholinesPyrazolesReceptor, Cannabinoid, CB1

Identifiers

PMID33216305
PMCPMC8528513
OpenAlexW3105597823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.